Renal - Nephritic/ Nephrotic Flashcards Preview

USLME Kiss my ass and pray > Renal - Nephritic/ Nephrotic > Flashcards

Flashcards in Renal - Nephritic/ Nephrotic Deck (15):
1

Goodpasture Syndrome presentation and cause

RPGN-(w/ wegeners)

Nephritic and pulmonary hemorrhage

hematuria, hemoptyisis, proteinuria and RBC casts

IgG to Basement Membrane(type 4 collagen)
Type II Hypersensitivity

2

Post streptococcal glomerulonephritis

Nephritic syndrome

lumpy bumpy appearance

IgG, IgM and and C3 deposition in GBM and mesangium

3

Berger's Disease

Nephritic

Mesangial IgA deposits

4

Alport Syndrome cause and presentation

Nephritic syndrome w/ deafness
-sometimes eye problems

Mutation in Type iV collagen

X linked

5

RPGN types(3) and presentation

Crescent moon shape w/ fibrin and plasma proteins - Nephritic

Goodpastures
- lungs and kidney
Wagners
-cANCA, gramulomas w/ polyangiitis
Microscopic polyangitis
-pANCA

6

Focal Segmental Glomeruloscerosis
-histology
- Associations (5)

Nephrotic
Most common cause in adults
segmental sclerosis and effacement of foot processes


Associated w/
HIV, heroine, obesity, IFN Rx, chronic kidney disease

7

Membranous nephropathy
-Histology
-Associations(4)

Nephrotic Syndrome

Spike and dome
diffuse capillary and GBM thickening

Second most common cause in adults

Associated w/
drugs, infection, SLE, solid tumors

8

Minimal change disease
- Histology
-Associations(2)

Nephrotic

Normal glomeruli

Most common in kids 2-6 yrs
Maybe triggered by infection or immune stim

9

Membrano-proliferative glomerulonephritis
- Histology
-associations

2 Types
Primarily nephrotic can be nephritic

Type 1 - tram track appearance of GBM due to splitting from mesangial ingrowth

-associated w/ HBV, HCV

Type 2 - dense deposits intramembranous
-associated w/ C3 nephritic factor

10

Diabetic glomerulonephropathy
-histology

Nephrotic

Nonenzymatic glycosylation

Mesangial expansion,

Kimmelstiel wilson lesions: esinophilic nodular glomerulosclerosis (PAS positive)
- hyaline masses

11

Glomerulonephritis w/ decrease C3 and C4 (2)

SLE
Poststrept Glomerulonephritis

12

Metabolic acidosis profile and cause

Primary - Low bicarb (<40)

- MUDPILES
-Breathing fast to blow off CO2 and compensate

13

Metabolic Alkalosis Profile and Cause

Primary -High bicarb (>24)

Secondary high PCO2 (>40)

-throwing up H,
breathing slow to try and retain CO2

14

Respiratory Acidosis Profile and Cause

Primary - High PCO2 (>40)

Secondary - high bicarb (>24)

- blockage/obstruction and kidneys retain bicarb to compensate

15

Respiratory Alkalosis Profile and Cause

Primary - Low PCO2 (<24)

- hyperventilating and blowing off CO2 faster than necessary. Kidneys are not resorbing bicarb to compensate