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Flashcards in Endocrine Disorders Deck (34)
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1

treatment for hypotensive patients with diabetes insipidus

normal saline

2

treatment for normotensive patients with diabetes insipidus

hypotonic saline (.45% saline or D5%)

3

17 alpha-hydroxylase deficiency

hypertension, hypokalemia, decreased sex hormones
XY: externally female, no internal structures
XX: externally female, normal internal structures, lacks secondary sex characteristics

4

21-hydroxylase deficiency

most common form
hypotension, hyperkalemia, increased renin
elevated 17-hydroxyprogesterone
masculinization, female pseudohermaphroditism

5

11 beta-hydroxylase deficiency

hypertension and masculinization

6

partial 21-hydroxylase deficiency

present in early adulthood with hyperandrogenism, not usually accompanied by salt wasting
increased levels of 17-hydroxyprogesterone, confirm with ACTH stimulation test

7

hypokalemia, alkalosis, normotensive blood pressure
urine chloride concentration is high

bartter syndrome
gitelman syndrome
diuretic abuse

8

most reliable indicator of metabolic recovery in patients with DKA

serum anion gap or arterial pH

9

acid/base status in primary hyperaldosteronism

metabolic acidosis
hypokalemia causes potassium to move out of cells into extracellular space, hydrogen ions then move into cells to maintain electrical neutrality

10

defective mineralization of bone

osteomalacia: vitamin D deficiency in adults

11

defective mineralization of bone and cartilage

rickets: vitamin D deficiency in children

12

disordered skeletal remodeling

paget's disease

13

defective formation of collagen

osteogenesis imperfecta

14

low bone mass with normal mineralization

osteoporosis: low bone mass but bone is normally mineralized per unit volume

15

most common cause of death in patients with acromegaly

congestive heart failure

16

MEN2a syndrome

medullary thyroid cancer
pheochromocytoma
parathyroid adenoma

ret gene

17

MEN2b syndrome

medullary thyroid cancer
pheochromocytoma
mucosal neuroma
marfinoid habitus

ret gene

18

MEN1 syndrome

pituitary adenoma
parathyroid adenoma
pancreatic islet cell tumor

menin tumor suppressor gene

19

treatment of pituitary adenoma

< 10 mm = microadenoma, treat with bromocriptine or cabergoline
surgery reserved for patients who do not respond to medication
radiation reserve for patients refractory still, as it has a slower response rate

20

cause of hypertension in thyrotoxicosis

systolic hypertension caused by hyperdynamic circulation

21

cause of hypertension in hypothyroidism

diastolic hypertension caused by increased systemic vascular resistance

22

causes of thyrotoxicosis with low radioactive iodine uptake

subacute painless thyroiditis
subacute granulomatous thyroiditis
iodine-induced thyroid toxicosis
levothyroxine overdose
struma ovarii

23

myxedema madness

paranoia and hallucinations in hypothyroidism

24

carpal tunnel syndrome with amyloid fibril deposition

amyloidosis secondary to end-stage renal disease or chronic hemodialysis

25

carpal tunnel syndrome with tenosynovial inflammation

rheumatoid arthritis

26

carpal tunnel syndrome with accumulation of matrix substances

hypothyroidism

27

carpal tunnel syndrome with accumulation of fluid in the carpal tunnel

pregnancy related volume overload

28

carpal tunnel syndrome with synovial tendon hyperplasia

acromegaly

29

where DHEA is produced

ovaries and adrenals

30

where DHEAS is produced

adrenals