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Flashcards in Endocrine Drugs Deck (27):
1

Short acting Insulins:

Just regular insulin

2

Intermediate acting Insulins:

NPH

3

Long acting insulins

Glargine, Detemir

4

Metformin use

First line in type 2 DM. decreases gluconeogenesis, increases glycolysis, increases peripheral glucose uptake

5

Metformin toxicity

GI upset, lactic acidosis (don't give in renal failure)

6

First Gen Sulfonylureas Names:

Tolbutamide, Chlorpropamide

7

Second Gen Sulfonylureas Names:

Glyburide, Glimepiride, Glipizide (short acting)

8

Sulfonylureas mechanism and use

Close K channels in beta-cells to depolarize cells and trigger insulin release. Used only in DM2.

9

Sulfonylureas toxicities

first gen no one cares: disulfiram effects
second gen is hypoglycemia

10

Glitaones names and mech

(-glitazone) Pioglitazone. increase insulin sensitivity via binding PPAR-gamma nuclear receptor

11

Glitazone use

monotherapy or combo in diabetes type 2

12

Glitazone tox

weight gain, edema, hepatotox, heart failure

13

Acarbose/Miglitol

alpha glucosidase inhibitors on brush boarder, stop sugar absorption. used in type 2 DM

14

Amylin mech and us

decreases glucagon. DM1/2

15

GLP1 analog/DPP4 inhib

(-tide)(-gliptin) increase insulin and decrease glucagon for DM2

16

Propylthiouracil, methimazole mech and use

Use: hyperthyroid
Mech: both-inhib peroxidase from organification of iodine to make T4. Propylthiouracil also blocks 5'-deiodinase to block peripheral T4->T3

17

Propylthiouracil/ methimazole toxicities

skin rash, aplastic anemia, agranulocytosis
Propyl: hepatotox
Methimazole: teratogen

18

Levothyroxine, triiodothyronine

Thyroxine replacement for hypothyroid. May cause tachycardia, heat intolerance, tremors, arrhythmias

19

Turner syndrome give them?

GH (still won't cause preggo)

20

Octreotide

Somatostatin: ACromegaly, carcionoid, gastrionoma, glucagonoma, esophageal varices

21

oxytocin

stim labor, uterine contractions, milk letdown, control utermine hemorrhage

22

Demeclocycline

ADH antagonist (tetracycline antibiotic), given in SIADH. tox: nephrogenic DI, photosensitivity, abnormal of bones and teeth

23

Glucocorticoids names

hydrocortizone, prednisone, triamcinolone, dexamethasone, beclomethasone

24

glucocorticoid mech

inhib phospholipase A2 and COX2 (no PG, LT)

25

Glucocorticoid uses

Addisons, inflammation, immune suppression, asthma

26

Glucocorticoid Tox

abrupt withdrawl causes adrenal insufficiency
can cause iatrogenic cushings (buffalo hump, moon face truncal obesity, muscle wasitng, thin skin)

27

Rapid Acting Insulins

LAG: Lispro, Aspart, Glulisine