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Flashcards in Renal Drugs Deck (21):
1

Mannitol: mechanism and use

osmotic diuretic. decreases ICP and intraocular pressure. used in drug overdose as well.

2

Mannitol: toxicity

pulmonary edema, dehydration. contraindicated in anuria, CHF

3

Acetazolamide mech and use

carbonic anhydrase inhibitor, diuresis with NaHCO3. used in glaucoma, urinary alkalinization, metabolic alkalosis, altitude sickness

4

acetazolamide toxicity

hyperchloremic metabolic acidosis (gap), paresthesia, ammonium tox, sulfa allergy

5

Furosemide mechanism

loop diuretic that blocks the triporter of the ascending loop, abolishing hypertonicity of medulla. loss of Calcium. also stims PGE release so give NSAID

6

Furosemide sides

OH DANG: Ototoxicity, hypokalemia, dehydration, allergy (this is a sulfa drug), Nephritis, Gout

7

Furosemide uses

edematous states (CHF, cirrhosis, nephrotic, pulm edema) hypertension, hypercalcemia

8

Ethacrynic acid

the non-sulfa loop diuretic. only difference is it makes gout worse.

9

Hydrochlorothiazide mechanism

inhibits NaCl reabsoption in early distal tubule, decreased calcium excretion

10

hydrochlorothiazide uses

hypertension, chf, idiopathic urine calcium loss, nephrogenic diabetes insipidus

11

Hydrochlorothiazide side effects

Hypokalemic metabolic acidosis and hyperGLUC (hyperGlycemia, hyperLipidemia, hyperUricemia, and hyperCalcemia). ALSO IS A SULFA

12

K sparing diuretics names

Spirnolactone, Triamterne, Amiloride (the K STAys)

13

mechanism of k sparing diuretics

spirnolactone is aldosterone receptor blocker, while triamterene and amiloride both block the sodium channel downstream of aldosterone

14

Spironolactone side effects

endocrine effects: gynecomastia, antiandrogen effects

15

ACE inhibitors names

captopril,enalapril, lisinopril

16

ACE inhibitor mech

no ATII = down GFR cause no efferent constriction. no inactivation of bradykinin (so vasodilation)

17

angiotensin ii recptor blockers

-sartans. same as ace but no bradykinin effect so no cough or angioedema

18

ace inhibitor use

hypertension, chf, proteinuria

19

ace inhibitor toxicity

Captopril's CATCHH: Cough, Angioedema, Teratogen, Creatinine increase, Hyperkalemia, Hypotension. Also don't use in renal artery stenosis cause it further decreaese GFR

20

Diabetes inspidous rx

Hydrochlorothiazide

21

Treatment for idiopathic urine calcium loss

Hctz