Viruses and AntiVirals Flashcards Preview

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Flashcards in Viruses and AntiVirals Deck (27):
1

killed vaccines

Rabies, influenza (injected), salk polio, HAV

2

the only ssDNA virus

Parvo

3

DNA viruses

HHAPPPPy: Hepadna, Herpes, adeno, pox, parvo, papilloma, polyoma

4

DNA viruses replicate where (and exception)

in nucleus except poxvirus (DNA-dep RNA pol)

5

only dsRNA virus

reovirus

6

RNA viruses

I went a RETRO TOGA party to drink FLAVored CORONA and ate HEPE (hippy) CALIfornia (calicivirus) PICORA (picorna)

7

ploidy of viruses

all are haploid except retroviruses (diploid)

8

Non-enveloped viruses

Hepe CPR (RNA), PAPP (DNA)
Calcivirus, Parvo, Reo
Papilloma, Adeno, Picorna, Polyoma

9

HSV1

#1 cause of encephalitis (temporal lobe), oral/facial, keratoconjunctivitis, latent in trigeminal
not STD, saliva

10

HSV2

genital herpes, neonatal, latant in sacral ganglia

11

VZV

HHV3: shingles/chickenpox, also encephalitis and pneumonia. latant in dorsal root or trigem ganglia

12

EBV

HHV4: mononucleosis (kissing), Burkitt's/Hodgkins lymphoma, nasopharyengocarcinoma, infects B cells, pharyngitis, hepatosplenomegaly, atypical T cells on smear, monospot test

13

CMV

HHV5: babies, monospot negative mononucleosis, retinitis (sight-o megalovirus), owls eyes inclusions, latent in mononuclear cels

14

HHV6

Roseola: high fever, seizures followed by diffuse macular rash

15

HHV8

Kaposi sarcoma seen in HIV. purple papules on skin and oral mucosa

16

Adenoviruses cause

DNA virus: pink eye (conjunctivitis), pneumonia, pharyngitis

17

Parvovirus

DNA virus
B19: aplastic crisis in sickle cell, fifth disease (slapped cheeks erythema), Rheumatoid arthritis, RBC destruction in fetus to cause hydrops fetalis

18

Polyomaviruses

DNA
JC: PML in AIDS
BK: kidney in transplant patients

19

Poxviruses

DNA Virus:
Smallpox
Vaccinia (cowpox)
Molluscum contagiosum (flesh dome)

20

Genetic material of Herpes HHV/HSV

DNA

21

live vaccines

smallpox, YFV, chicken pox, Sabin polio, MMR, Influ

22

zanamivir, oseltamivir

inhibits influenza neuraminidase decreasing release of progeny

23

ribavirin mech and use

inhibits guanine nucleotide synthesis by blocking IMP dehydrogenase. RSV and chronic hepatitis C

24

acyclovir mech and use

Monosphorylated by HSV/VZV thymidine kinase, viral DNA chain termination. Herpes viruses HSV1/2 and VZV. Weakly EBV, no activity with CMV. used for controling lesions and encephalopathy and prophalaxis

25

Ganciclovir mech and use

5' Monophosphate formed by CMV kinase, Guanosine analog. used in CMV immunocompromized.

26

Foscarnet

viral DNA pol inhibitor/binds pyrophosphate site (no need for viral activation). used in CMV and HSV which have resistance since it doesn't need viral kinase. Pyrophosphate analog .

27

Cidofovir

inhibits viral DNA pol, doesn't need viral kinase