Endocrine Drugs - Drugs Affecting Bone Mineral Metabolism Flashcards Preview

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Flashcards in Endocrine Drugs - Drugs Affecting Bone Mineral Metabolism Deck (34):
0

What is the mechanism of action of cholecalciferol/ergocalciferol?

Regulates gene transcription via the vitD receptor to produce its effects.

1

What is the clinical application of cholecalciferol/ergocalciferol?

VitD deficiency

2

What are the pharmacokinetics of cholecalciferol/ergocalciferol?

1. Oral administration
2. Metabolism in liver or kidney to active forms

3

What are the toxicities of cholecalciferol/ergocalciferol?

1. Hypercalcemia
2. Hyperphosphatemia
3. Hypercalciuria

4

What is the clinical application of calcitriol?

1. Used for management of secondary hyperparathyroidism in patients with chronic kidney disease.
2. Management of hypocalcemia in hypoparathyroidism.

5

Does calcitriol require metabolism to form an active form?

No.

6

Where is doxercalciferol used?

Management of secondary hyperparathyroidism in patients with chronic kidney disease.

7

Mention an analog of calcitriol.

Paricalcitol

8

Mention an analog of calcitriol approved for psoriasis.

Calcipotriene

9

What is the mechanism of action of alendronate?

Suppresses the activity of osteoclasts and inhibits bone resorption.

10

What are the clinical applications of alendronate?

1. Osteoporosis
2. Paget's disease

11

How is alendronate administered?

Orally daily or weekly.

12

What are the side effects of alendronate?

1. Adynamic bone
2. Esophageal irritation
3. Osteonecrosis of the jaw (rare)

13

Mention 4 drugs similar to alendronate?

1. Risedronate
2. Ibandronate
3. Pamidronate
4. Zoledronate

14

What is the mechanism of action of Teriparatide?

Acts through PTH receptors to produce a net increase in bone formation.

15

What is the clinical application of teriparatide?

Osteoporosis

16

How is teriparatide administered?

Subcutaneous injection

17

What are the side effects of teriparatide?

1. Hypercalcemia
2. Hypercalciuria
3. Osteosarcoma in experimental animals

18

What is the mechanism of action of calcitonin?

Acts through calcitonin receptors to inhibit bone resorption.

19

What is the clinical application of calcitonin?

Osteoporosis

20

How is calcitonin administered?

SC injection or intranasally.

21

What is a possible side effect of calcitonin?

Rhinitis with the nasal spray.

22

What is the mechanism of action of raloxifene?

1. Estrogen agonist effect in bone.
2. Estrogen antagonist effects in breast and endometrium.

23

What is the clinical application of raloxifene?

Osteoporosis in postmenopausal women.

24

How is raloxifene administered?

Orally

25

What are the side effects of raloxifene?

1. Hot flushes
2. Thromboembolism

26

What is the mechanism of action of denosumab?

Binds to RANKL and prevents it from stimulating osteoclast differentiation and function.

27

What is the clinical application of denosumab?

Osteoporosis

28

How is denosumab administered?

SC every 6 months.

29

What is a possible side effect of denosumab?

It may increase risk of infections.

30

What is the mechanism of action of cinacalcet?

Activates the calcium-sensing receptor.

31

What is the clinical application of cinacalcet?

Hyperparathyroidism

32

How is cinacalcet administered?

Orally

33

What are the side effects of cinacalcet?

1. Nausea
2. Hypocalcemia
3. Adynamic bone

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