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Flashcards in Epidemiological study design Deck (14):
1

Give 6 types of study design

Cohort study, case-control, ecological, cross-sectional, RCT, meta-analysis

2

describe the design of a cohort study

An observational study

Longitudinal study in similar groups but with different risk factors/treatments

Follow up over time (constantly checking in)

(in contrast to case-control, the outcome has not occurred yet)

3

Describe case-control studies

An observational study looking at the cause of a disease. Compares similar participants w/ disease and those without (controls). Looks RETROSPECTIVELY for exposure/cause (potential RF data is collected - e.g. questionnaires)

The outcome has already occurred at the time of investigation

important idea: looks backwards in time

4

describe ecological studies

Observational study of a disease or outcome and exposure of interest are measured in a number of populations/groups (e.g. between electoral wards or different hospitals)

5

describe a cross-sectional study

Observational study collecting data from a population at a specific point in time (no follow-up) - a SNAPSHOT STUDY

Example: the census (conducted every 10 years) --> other examples include prevalence at a specific time (e.g. number of smokers in a GP practice)

6

describe an RCT

Experimental study

Similar participants are randomly assigned to an intervention or control group to study effect of intervention

7

What are the advantages and disadvantages of an RCT?

Advantages:
- Low risk of bias and confounding
- Comparative
- randomised
- blind - reduces possibility of information bias

Disadvantages:
- High drop out rate
- Ethical issues
- Time consuming and expensive
- prior knowledge required

8

What are the advantages and disadvantages of an ecological study?

Advantages: can lookout geographical correlations, good for generating a hypothesis

Disadvantages:
- subject to bias + confounding

9

What are the advantages and disadvantages of a cohort study?

Advantages:
- Can follow up rare exposure
- Allows to identify risk factors
- Data on confounders collected prospectively

Disadvantages:
- Large sample size required
- Impractical for rare diseases
- Expensive
- People drop out
- Confounding/bias

10

What are the advantages and disadvantages of a case control study?

Advantages:
- Quick
- Good for rare outcomes

Disadvantages:
- Difficult finding appropriately matched controls
- Prone to selection and information bias (e.g. recall bias)
- dropout
- Reverse causality (as the outcome interest has already occurred)

n.b. all the observational studies (case control, ecological, cohort, cross-sectional) are subject to bias and confounding

11

What are the advantages and disadvantages of a cross-sectional study?

Advantages:
- Large sample size
- Provides data on prevalence of risk factors and disease
- Quick to carry out
- Repeated studies show changes over time

Disadvantages:
- Risk of reverse causality – which came first?
- Less likely to include those who recover quickly or short recovery
- Not useful for rare outcomes
- subject to bias + confounding
- Temporality: impossible to be certain whether an outcome developed before or after the exposure concerned

12

What is a meta-analysis?

An evidence synthesis where all the data of similar studies are pooled together and a forest plot is created

13

What is an ethical dilemma of RCTs?

is it ethical to withhold potentially life-saving treatment form the control group?

14

Give an example of a cross-sectional study

Census