Flashcards in Epidemiology revision Deck (33):

1

## What is epidemiology?

### The study of frequency, distribution + determinants of diseases and health related states in populations in order to prevent + control disease

2

## What is the difference between prevalence + incidence?

###
Incidence (cumulative incidence):

- New cases

- Denominator (number of disease free people at the start of the study)

- Time

Prevalence:

- existing cases

- denominator (the population at risk of having that disease)

- point in time (point prevalence)

3

## What is person-time?

###
A measure of time at risk - i.e. the time from entry to a study to (i) disease onset, (ii) lost follow-up or (iii) end of study

Used to calculate INCIDENCE RATE which uses person-time as a denominator (new cases/person-time)

(can be person-years)

4

## What does cumulative incidence use as the denominator?

### The number of disease free people at start of study

5

## What is incidence rate useful for?

### When study participants are followed up for varying lengths of time

6

## How do you calculate incidence rate? (SBA exam Q)

### (Number of new cases in a given time period) / (total person-time at risk during that time)

7

## What are the usual headings used when describing the epidemiology of a disease?

###
1. time

2. place

3. person (age, gender, class, ethnicity)

8

## What is (absolute) risk?

### (the number of events) / (the total population at risk over a given time period)

9

## What is the difference between absolute and relative risk? (Exam)

###
(Absolute) risk: gives a feel for actual numbers involved (has units) --> e.g. 50 deaths / 1000 population

Relative risk: risk in one category relative to another (i.e. no units)

10

## What is attributable risk vs relative risk?

###
Attributable risk: The rate of disease in the exposed that may be attributed to the exposure (i.e. incidence in exposed minus incidence i unexposed. Also called 'absolute excess risk' (it is a type of absolute risk)

Attributable risk = absolute risk one group - absolute risk of other group

Relative risk: ratio of risk of disease in the exposed (e.g. treatment group or smokers...) to the risk in the unexposed (e.g. placebo group) (i.e. incidence in exposed divided by incidence in unexposed)

both are used to COMPARE two groups (e.g. see if smoking carries greater risk than non-smoking to lung cancer)

Relative risk tells us about the STRENGTH of association between a risk factor and a disease

Attributable risk is about the size of effect in absolute terms (i.e. gives a feel for the public health impact - if causality is assumed)

11

##
Calculate the attributable risk + relative risk between these two groups:

Incidence of Disease A in smokers, 1/1000 person-years

Incidence of Disease A in non-smokers, 0.05/1000 person-years

###
Attributable risk: 1/1000 - 0.05/1000 = 0.95/1000 person-years

Relative risk: (1/1000) / (0.05/1000) = 20 (no units)

12

##
Calculate the attributable risk + relative risk between these two groups:

Incidence of Disease B in smokers, 8/1000 person-years

Incidence of Disease B in non-smokers, 4/1000 person-years

###
Attributable risk: 8/1000 - 4/1000 = 4/1000 person-years

Relative risk: (8/1000) / (4/1000) = 2 (no units)

13

## In the previous examples, why was the attributable risk smaller for Disease A compared with Disease B even though the relative risk is much larger?

### Because Disease B is more common

14

## How do you calculate absolute risk difference/reduction?

### Highest cumulative incidence of one group MINUS the cumulative incidence of the other group (or either way but take away the negative sign)

15

##
How do you calculate number needed to treat (to avoid one case of disease X)?

How do you calculate relative risk reduction?

###
NNT = 1 / (absolute risk reduction)

Relative risk reduction = 1 - relative risk (remember if relative risk is % convert to decimal)

16

##
From the following (RCT w/ 5-yr follow-up), calculate the absolute risk reduction, relative risk, number needed to treat, relative risk reduction:

Cumulative incidence of Disease X in people given a new treatment is 6/1000

Cumulative incidence of Disease X in people on placebo is 10/1000

###
Absolute risk reduction/difference = 4/1000 (over 5 years)

i.e. 1000 people treated and four cases if disease avoided

Relative risk = 0.6

i.e. Incidence in treatment group / Incidence in placebo group

Number needed to treat (to avoid one case of Disease X) = 1 / (absolute risk reduction: 4/1000) = 250

Relative risk reduction = 40% (or 0.4) i.e. relative risk reduced by 0.4 (1-0.6)

17

## Summary of some risk terms

###
AR (absolute risk) = the number of events (good or bad) in treated or control groups, divided by the number of people in that group.

ARC = the AR of events in the control group.

ART = the AR of events in the treatment group.

ARR (absolute risk reduction) = ARC – ART.

RR (relative risk) = ART / ARC

18

## What is bias?

### A systematic deviation from the true estimation of the association between exposure and outcome

19

## What are the 3 types of bias?

###
1. selection bias

2. information (measurement) bias

3. publication bias - studies with -ve results less likely to be published

20

## Give an example of bias

### E.g. comparing mean BP of people in Sheffield and Rotherham -> there may be measurement bias in that two different nurses (dif skills) are measuring BP and a different BP machine is used. Or selection bias

21

## What is selection bias?

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A systematic error in:

- the selection of participants

- the allocation of participants to different study groups

22

## What is information (measurement) bias?

###
A systematic error in measurement of:

- exposure

- outcome

23

## What are the sources of information bias?

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- Observer (e.e. observer bias)

- Participant (e.g. recall bias or reporting bias)

- Instrument (e.g. wrongly calibrated instrument)

24

## What is confounding?

### The situation where a factor is associated with the exposure of interest + independently influences the outcome (but doesn't lie on the causal pathway)

25

## Give an example of a cofounding variable in a study

###
Study looking at drinking coffee and lung cancer link

Smoking is a confounding variable in this

26

## What must you consider when looking at association and causation?

### Bias, chance, confounding, "criteria" for causality

27

## What is the Bradford-Hill criteria for causality (i.e. what factors to consider when assessing causality)? - know 4

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Dose-response: the higher the exposure, the higher the risk of disease

Consistency: similar results from different researchers using various study designs

Temporality: does exposure precede the outcome?

Reversibility (experiment): removal of exposure reduces risk of disease

Biological plausibility: biological mechanisms explaining the link

others: analogy, coherence, strength of association, specificity

28

## If an association/correlation is not causal, how can it be explained?

###
(- causal)

- bias

- chance

- confounding

- reverse causality

29

##
What is reverse causality

give an example of reverse causality

###
Situation where where an association between an exposure + outcome is due to the outcome causing the exposure

study examining idea that stress causes HTN: Study shows HTN pts have higher stress levels (consistent with the hypothesis) BUT HTN could have caused ^ stress levels (reverse causality)

30

## What is lead time bias?

### lead time is the length of time between detection of the disease and its usual clinical presentation - apparent ^ in survival time

31

## What is length-time bias?

### Disease that progress more slowly is more likely to be picked up by screening (i.e. symptom free and around for longer) than more rapidly progressing diseases

32

## What types of bias can be seen in screening?

###
lead time bias

length time bias

selection bias

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