Flashcards in Epithelial arch. Deck (68)
Cell-cell junctions regulate gene expression which is important in what 2 processes?
Cancer development, tumor metastases
The ___________ plays a role in initiating cell-cell communication
____________ is usually degraded by ubiquitin and is normally linked to e-cadherin
The ________-bound form of tubulin polymerizes which the ________-bound form depolymerizes
Cell-cell contact is mediated by what anchor protein?
Cell-matrix interactions are mediated by what proteins?
What filament is the most stable? Why is that?
Intermediate filaments, they are not polarized
What filament provides mechanical strength?
Desmosomes function to attach cell surface adhesion molecules but what other function do they serve?
Cell-cell contact signals
_____________ helps organize cell content and organelles
Phalloidin acts on what filament?
Growing microtubules have ____ bound while shrinking have _____ bound. Actin polymerizes with _______ bound to it and destabilizes with _________ bound.
GTP, GDP, ATP, ADP
Actin polymerization controls what 3 cell movement structures? What do they do?
Lamellipodia - two dimensional sheets
Pseudopodia - 3D projections in neutrophils
Actin filament grow by the process of ____________ which involves ________ _________ proteins.
Listeria monocytogenes seeks to mimic what?
What are the four types of cell-cell junctions?
Anchoring - hold cells in place
Occluding - separates basal and apical
Channel-forming - allows cell communication
Signal-relaying - NMJ
Weak adhesion forces are due to ___________ receptors, while stronger forces are due to __________
__________ ____________ seals gap between epithelial cells
___________ _________ connects actin filaments in one cell to the actin in the next
_______________ connects intermediate filaments in one cell to those in the next cell
_________ _____________ allow the passage of small water soluble molecules and ions from cell to cell
_________________ anchors intermediate filaments in a cell to extracellular matrix
What 4 things does a tight junction do?
Recruit signaling molecules
Form a fence
Gap junctions allow molecules smaller than __________ da to pass through.
What two proteins are related to gap junctions?
Connexin and innexin
Connexin is composed of ____ subunits
What causes gap junctions to immediately close as to not affect nearby cells
What stops leukocytes at the site of inflammation?
Intergin affects proliferation, differentiation, protein synth., attachment, migration, and shape change through what process?
Integrins form focal adhesion complexes which tell the nucleus what changes need to be made