Epithelial arch. Flashcards Preview

MCM Final > Epithelial arch. > Flashcards

Flashcards in Epithelial arch. Deck (68)
Loading flashcards...
1

Cell-cell junctions regulate gene expression which is important in what 2 processes?

Cancer development, tumor metastases

2

The ___________ plays a role in initiating cell-cell communication

Desmosome

3

____________ is usually degraded by ubiquitin and is normally linked to e-cadherin

Beta-catenin

4

The ________-bound form of tubulin polymerizes which the ________-bound form depolymerizes

GTP, GDP

5

Cell-cell contact is mediated by what anchor protein?

Desmosomes

6

Cell-matrix interactions are mediated by what proteins?

Hemidesmosomes

7

What filament is the most stable? Why is that?

Intermediate filaments, they are not polarized

8

What filament provides mechanical strength?

Intermediate filament

9

Desmosomes function to attach cell surface adhesion molecules but what other function do they serve?

Cell-cell contact signals

10

_____________ helps organize cell content and organelles

Actin (microfilaments)

11

Phalloidin acts on what filament?

Actin

12

Growing microtubules have ____ bound while shrinking have _____ bound. Actin polymerizes with _______ bound to it and destabilizes with _________ bound.

GTP, GDP, ATP, ADP

13

Actin polymerization controls what 3 cell movement structures? What do they do?

Filopodia-microspikes
Lamellipodia - two dimensional sheets
Pseudopodia - 3D projections in neutrophils

14

Actin filament grow by the process of ____________ which involves ________ _________ proteins.

Nucleation, actin-related

15

Listeria monocytogenes seeks to mimic what?

ARP

16

What are the four types of cell-cell junctions?

Anchoring - hold cells in place
Occluding - separates basal and apical
Channel-forming - allows cell communication
Signal-relaying - NMJ

17

Weak adhesion forces are due to ___________ receptors, while stronger forces are due to __________

Heterophilic, homophilic

18

__________ ____________ seals gap between epithelial cells

Tight junction

19

___________ _________ connects actin filaments in one cell to the actin in the next

Adherens junction

20

_______________ connects intermediate filaments in one cell to those in the next cell

Desmosome

21

_________ _____________ allow the passage of small water soluble molecules and ions from cell to cell

Gap junction

22

_________________ anchors intermediate filaments in a cell to extracellular matrix

Hemidesmosome

23

What 4 things does a tight junction do?

Recruit cytoskeleton
Recruit signaling molecules
Form a fence
Vectorial transfer

24

Gap junctions allow molecules smaller than __________ da to pass through.

1000

25

What two proteins are related to gap junctions?

Connexin and innexin

26

Connexin is composed of ____ subunits

6

27

What causes gap junctions to immediately close as to not affect nearby cells

Ca

28

What stops leukocytes at the site of inflammation?

Integrins

29

Intergin affects proliferation, differentiation, protein synth., attachment, migration, and shape change through what process?

Integrins form focal adhesion complexes which tell the nucleus what changes need to be made

30

What does vinculin bind to?

Actin