EX3; Oral Mucosa Flashcards Preview

May14 Oral Histology > EX3; Oral Mucosa > Flashcards

Flashcards in EX3; Oral Mucosa Deck (83):
1

The mouth is lined by what

moist mucous membrane (must like the nasal passageway ad GI tract)

2

What two tissues is the mucous membrane organ composed of

epithelium
lamina propria

3

What is the lamina propria

connective tissue (+submucosa sometimes)

4

What lies in the lamina propria and submucosa

blood vessels (submucosa too)
salivary glands (submucosa most prominenmt location)

5

What is the function of salivary glands

lubricate the surface via ducts

6

Ducts from both the major and minor salivary glands travel through the connective tissue to communicate with what

the mucosal surface

7

What are the main functions (3) of the oral mucosa

protection; barrier and antimicrobial
ingestion

8

What specific molecule in the oral mucosa is used as an antimicrobial

beta-defensins

9

True or False
The oral mucosa is HIGHLY innervated

True

10

What types of sensations can the oral mucosa detect

touch
pain
termal
taste

11

All oral epithelium is what kind of epithelium

stratified squamous epithelium

12

This is the self-renewing layer of the epithelium

deep layers; undergo cell division

13

This layer migrates and matures, then is sloughed of

superficial layer

14

What is the turnover time of oral epithelium

relatively fast
it speeds healing but also makes the tissues more vulnerable to conditions that affect cell division

15

Diffuse mucositis/ulcer and extensive ulceration can be the effect of what

head/neck radiotherapy

16

Most of the volume of the epithelium is occupied by what

cells

17

What are the most numerous cells in the epithelium

keratinocytes

18

These are pigment cells found in the basal layers

melanocytes

19

These are immune cells found in the supra-basal layers

Langerhans (dendritic) cells

20

These are sensory cells found in the basal layers

Merkel cells

21

Non-keratinocytes are identified as clear cells due to what

lack of cytokeratin staining

22

What are some examples of keratinized and non-keratinized oral mucosa

keratinized = gingiva, hard palate
non-keratinized = alveolar mucosa, soft palate, buccal mucosa

23

This layer of epithelium is due to the appearance of desomosomes

prickle layer

24

What is the appearance of keratinized epithelium

no organelles
dehydrated; flat
tougher

25

What is the appearance of non-keratinized epithelium

organelles
flexible

26

True or False
All epithelial cells contain keratinocytes, which contain cytokeratins

True; even non-keratinized

27

This is a large multi gene family of proteins, split into type 1 (acidic) and type 2 (basic)

cytokeratins

28

The cytokeratins assemble into what cytoskeletal support element

intermediate filaments

29

What is the structure of the intermediate filaments

central helical core flanked by non-helical ends; coiled heterodimer
each cell expresses 2 cytokeratins
10k heterodimers = intermedaite filament

30

What is the strength of the intermediate filaments

they are the strongest cytoskeletal element

31

Intermediate filaments are the intracellular components of what

desmosomes and hemidesmosomes

32

This is a rare, blistering in response to minor trauma, and most severe in epidermis disease

epidermolysis bullosa simplex
mutation in cytokeratin

33

True or False
different epithelial layers and tissues contain characteristic cytokeratins

True

34

Cytokeratin expression can change with what

disease state

35

Mutations in cytokeratin genes can produce what

regionally-specific diseases

36

This type of epithelium is tougher and more impermeable

keratinized

37

This type of epithelium is more flexible

non-keratinized

38

The amount of cytokeratin increases in what, in both non-keratinzied and keratinized epithelium

superficial layers (although more in keratinized)

39

What are two biochemical properties of cytokeratins

promotes aggregation
permits binding with fillagrin

40

What molecule promotes aggregation involving cytokeratins

Tonofibrils

41

What molecule permits binding with fillagrin involving cytokeratins

keratohyalin granules

42

The cytokeratin type in non-keratinized epithelium does not promote what

aggregationg; cannot complex with fillagrin

43

What do the superficial layers of non-keratinized epithelium look like

not flat/dehydrated
retain nuclei
cytokeratin tonofilaments

44

These are membrane bound organelles filled with gylcolipids first appearing in the upper prickle layer and released in more superficial layers to coat cell

membrane coating granules

45

What do membrane coating granules do

serve as an intercellular barrier to aqueous substances

46

This serves as an effective barrier in keratinized epithelium

differences in chemical composition

47

This is a 15nm cross-linked protein sheath comprised of loricrin and other proteins which is highly permeable to fluids passing

cornified envelope

48

Differences in membrane thickening produces what

an effective paracellular permeability barrier in keratinized epithelium

49

What are two variations in keratinization

incomplete keratinization
hyperkeratinization

50

What is the majority of the lamina propria volume occupied by

ECM

51

What additional cells are present in the lamina propria

fibroblasts
macrophages
mast cells
other inflammatory cells

52

What cells around found in the ECM of lamina propria

PGs and GAGs
glycoproteins
collagen type I and III
elastin

53

The relative amount of type 1:type 3 collagen is greater for what

less flexible regions of the oral cavity

54

This is more prominent in the oral mucosa than in the pulp or PDL

elastin

55

The epithelial/connective tissue interface is considered what

convoluted

56

What makes up the epithelial/connective tissue convoluted interface

epithelial rete pegs
connective tissue papillae
papillary and reticular layers

57

This component of the gingiva reflects the underlying pegs and connective tissue papillae

stippling

58

This is present under some regions of oral mucosa containing larger blood vessels and nerves supplying LP glands

submucosa

59

What does the submucosa separate the lamina prorpia from

bone and muscle

60

What are the three specialization of the oral mucosa

lining
masticatory
specialized

61

These structures make up the masticatory mucosa

hard palate
gingiva

62

These structures make up the lining mucosa

alveolar mucosa
soft palate
cheek
underside of tongue
floor of mouth

63

These structures make up the specialized mucosa

dorsal tongue
vermillion border

64

This is non-keratilized epithelium with variable thickness; thicken in the buccal mucosa, thinner in the FOM; short, broad papilla with a present submucosa

lining mucosa

65

What kind of fibers does the lamina propria of the lining mucosa contain more of

elastic fibers

66

What would occur is an incision/injection is made in the lining mucosa

incision; gaping, needs suturing
injection; less painful

67

This part of the lip region is keratinized, thin, blood vessels are close to surface, and no sweat/mucous glands

vermillion border

68

This part of the lip region is keratinized, thinnest, and contains sweat glands and hair follicles

exterior skin

69

This part of the lip region is non-keratinized, thicker, and contains mucous glands

labial mucosa

70

This is keratinized with dense lamina propria with more collagen, with many long thin connective tissue papillae

masticatory mucosa

71

This is variably present in hard palate and not present in rugae, along the midlines raphe, and adjacent to gingiva

submucosa

72

In masticatory mucosa, submucosa is not in gingiva, but what is

mucoperiosteum

73

What would occur is an incision/injection is made in the masticatory mucosa

incision; doesn't not gape, no sutures
injection; painful

74

This is part of free gingiva which faces tooth, generally non-keratinized

sulcular epithelium

75

This forms seal with hard tissues tooth, and is orientated along the long axis of the tooth, around 15-30 cells thick at top and 3-4 at the bottom

junctional epithelium

76

What kind of basement membrane does the junctional epithelium have

straight

77

What is the differenetion level of the junctional epithelium

relatively non-differentiated cells

78

How permeable is the junctional epithelium

highly permeable

79

What are the two basal laminas of the junctional epithelium

external; between JE and LP
internal; between JE and tooth

80

What is absent in the internal basal lamina of the junctional epithelium

collagen components

81

This is a protein expressed in the junctional epithelium

odontogenic ameloblast-associated protein ODAM

82

True or False
Junctional epithelium can regenerate relatively rapid and around dental implants

True

83

This was sued to demonstrate blood vessels in the papillary layer of gingiva

fluorescein angiography