EX3; Salivary Glands 1 Flashcards Preview

May14 Oral Histology > EX3; Salivary Glands 1 > Flashcards

Flashcards in EX3; Salivary Glands 1 Deck (70):
1

Reduced salivation can cause what

increased incidence of caries

2

What two conditions have particularly potent hypo salivation effects

head and neck radiotherapy
Sjogren's syndrome

3

This is the injection of an isotope of Technetium, which binds to Na-K-Cl membrane transport system of acinar cells of salivary and other glands; used in the case study of the boy with no saliva

salivary gland scintigraphy

4

True or False
genetic abnormalities of major salivary glands are fairly common

False; they are rare

5

True or False
genetic abnormalities of major salivary glands may involve a single or multiple glands

True

6

What may salivary gland agenesis be accompanied by

other developmental disorders of the ectoderm or 1st branchial arch
abnormalities of the hair, nails, missing teeth, or deafness

7

What is the severity of of salivary gland genesis dependent upon

the number of glands affected
type of abnormality; total lack of gland vs hypofunction

8

What is important to do regarding salivary gland agenesis

early diagnosis and immediate measures to prevent caries

9

These are highly glycosylated glycoproteins that are viscous and responsible for lubricating the mucosal surface and providing a protective barrier

mucins

10

What do mucins tranp and clear

bacteria and sugar

11

This is secreted in saliva and serves an important function in buffering acids in the mouth (neutralization of acids and pH maintenance)

bicarbonate

12

These are calcium-binding proteins present in saliva; allowing saliva to be super saturated and contribute to enamel maturation and remineralization

proline-rich proteins
statherin

13

These molecules contribute to the direct antimicrobial function os saliva (anti-bacterial, anti-fungal, anti-viral, etc.)

lysozyme
peroxidase
defensins
histatins
IgA

14

Some evidence suggests that saliva secretes this to actively participate in tissue repair

growth factors
epidermal growth factor
nerve growth factor

15

This provides lubrication that is critical to chewing and swallowing

mucins

16

Saliva contains these two enzymes which being to break down starch and fats into free fatty acids and glycerol

amylase = starch
lipase = fats

17

Taste molecules must first be dissolved in this so they can be transported to the taste buds

water

18

Salivary glands are considered which type of glands

exocrine

19

How do salivary glands discharge their secretion

via a duct to an epithelial surface

20

What are the three major salivary glands

parotid
submandibular
sublingual

21

What is the normal daytime salivary flow rate

0.3-04 ml/min

22

What is the normal daytime volume of saliva in the mouth

0.8-1.1ml; most of it is a thin film that covers the teeth

23

This major salivary gland secretes a mixed but mostly mucous secretion and 7-8% of the total volume

sublingual

24

This major salivary gland secretes a serous (watery) saliva with amylase and around 60% of the total volume

parotid

25

This major salivary gland secretes a mixed but most serous saliva and 25% of the total volume

submandibuar

26

What are the minor salivary glands

Von Ebner glands
labial
palatal
buccal
lingual

27

What do the Von Ebner glands secrete (serous)

lingual lipases

28

What do the labial, palatal, buccla, and lingual glands secrete (mucous)

mucins

29

This salivary gland's anterior end wraps around the caudal end of the mylohyoid and the duct travels superficially to empty into the oral cavity at Wharton's duct

submandibular

30

This salivary gland is the largest and sits superficial to the caudal end of the masseter, and discharges saliva through Stenson's duct

parotid

31

This salivary gland is the smallest and empties into a series of ducts behind Wharton's duct called Bartholin and Rivinus ducts

sublingual

32

This serves as the supporting role of the salivary gland forming a capsule and organizing the gland into lobes

stroma

33

This serves as doing the characteristic work of the given gland; making saliva and discharging it to the final destination

parenchyma

34

The stroma is made up of what type of tissue

connective tissue

35

The parenchyma is make up of what type of tissue

epithelium

36

This divides the gland into lobes (large) and lobules (minor)

septa

37

This produces collagen in the stroma

fibroblasts

38

These supply the parenchyma in the stroma

blood vessels
nerve fibers

39

This secretes antibodies in the stroma

plasma cells

40

This increases with age in the stroma

fat calls

41

During which embryonic week do the salivary glands begin development

6th

42

What is the order of gland development

parotid
submandibular
sublingual
minor glands (2-3 months)

43

Where is the parenchyma of both the acini and ducts derived from

ectoderm (parotid) or endoderm

44

Where is the stroma derived from

neural crest

45

What are the two main components of the parenchyma

secretory portion called acini
ducts

46

What are the acini composed of

individual acinar or secretary cells; they make saliva

47

What are the two main types of acinar cells

serous
mucous

48

The acini open up into a series of what kind of ducts, which get progressively larger

intercalated started (secretory)
excretory

49

The initiation of salivary gland development begins which what

the thickening of the ectoderm or endoderm forming a bud; signals exchanged between ectoderm/endoderm and mesenchyme

50

Once the salivary bud branches, what occurs

more branching then part of the branching hollows out in process known as cavitation

51

This molecule is important in cell adhesion, but disappears upon clefting/branching of the gland

e-cadherin

52

True or False
The cell turns off its expression of e-cadherin, making way for branching to occur

False; it does not turn off the expression, it just re-directs it

53

This molecular is important for clefting to occur

BTBD7 (cleftin); siRNA's were used to inhibit it

54

Cleftin is induced by what ECM molecule

fibronectin

55

What two actions does cleftin do

suppresses the expression of e-cadherin
upregulates expression of snail2

56

What is the current hypothesis involving snail2

promotes change in cell shape, coupled with the loss of e-cadherin

57

True or False
The acini secrete saliva

True

58

True or False
The ducts only secrete saliva

False; they also resorb certain components

59

This is the primary secretion or primary saliva

water
proteins and ions like Na and Cl

60

True or False
the primary secretion/saliva is isotonic

True

61

True or False
acinar cells are not water permeable, which duct cells are water permeable

False;
acinar cells are water permeable
duct cells are not

62

What does the duct cells secrete

few proteins like bicarbonate

63

True or False
The secondary secretion/saliva is isotonic

False; it is hyoptonic

64

Salivary secretion is under what control

neural control; parasympathetics and sympathetics

65

Which cranial nerves play a role in salivary gland innervation

7 - facial
9 - glossopharyngeal

66

The sympathetic supply to the salivary glands originates where

in the IML of the spinal cord then to the superior cervical ganglion

67

The sympathetic nervous system is responsible for what kind of secretion

protein

68

Activation of the sympathetic nervous system along produces what

a protein-laden, viscous secretion that is not voluminous

69

The parasympathetic nervous system is mainly responsible for what kind of secretion

fluid secretion that account for most of the volume of saliva

70

In the salivary gland cells, this is maintained at high intracellular concentration with an energy-requiring ion pump

chloride