Exam 1 Review pt.2 Flashcards
(54 cards)
What does a CBC consist of?
RBC
H&H
MCV & MCHC
What is hemoglobin?
The iron containing pigment of the RBC
(the seats)
(carry O2)
What is important when taking labs into consideration
Trending the labs
Causes of anemia
Bleeding
Bone marrow failure
Dietary deficiency
Renal disease
Causes for increase H&H
Polycythemia (too many RBC’s)
Dehydration
What protein transports iron?
Serum transferrin
What protein stores iron?
Serum ferritin
What is the most sensitive test to determine iron deficiency anemia
Serum ferritin
What test indicates whether the body is attacking its own RBC?
Direct coombs
What test is used to screen for antibodies prior to blood transfusion?
Indirect coombs
Indications for bone marrow biopsy
Unexplained anemia
Thrombocytopenia
Leukopenia
(when we do not know the cause)
Three main causes for anemia
- Decrease production (iron-b12-folic-kidney-liver)
- Blood loss (trauma) (ulcer)
- Increase destruction (sickle cell) (medication) (blood transfusion)
Decreased RBC production anemias
Iron deficiency
(hgb synthesis)
Cobalamin b12
Pernicious b12
Folic acid deficiency
(Defective DNA synthesis)
aplastic
renal failure
medication
(Decrease number of RBC precursors)
Megaloblastic anemias are caused by
Impaired DNA synthesis
What Hgb level is considered severe and will often result in blood transfusion?
6 g/dL
Anemia clinical manifestations
Weakness
Fatigue
Pallor
Increase HR
Bone pain
Angina
Dyspnea
Increase RR
Clinical manifestations of iron deficiency anemia
PALLOR = #1 (loss of demarcation)
Glossitis (tongue)
Cheilitis (lips)
Koilonychia (spoon nails)
Pica
Pagophagia
Iron deficiency morphology
Microcytic (small)
Hypochromic (pale)
Who gets cobalamin deficiency anemia
Pernicious anemia (no IF)
Hx of bowel surgery
Strict vegans
Alcohol abuse
Cobalamin Deficiency Clinical Manifestations
NEUROMUSCULAR
-weakness
-paresthesia
-ataxia
-impaired thought
Abdominal Pain
N/V
Glossitis
Cheilitis
Decrease RBC due to decreases hgb synthesis
Iron deficiency anemia
Decreased RBC due to defective DNA synthesis
Cobalamin
Pernicious
Folic
Aplastic Anemia results in
Pancytopenia
Decrease:
Platelets
RBC
WBC
Aplastic Anemia Morphology
Normocytic normochromic