Exam 2: Antibiotics-Quinolones, Metronidazole, Misc, AminoGlycosides Flashcards Preview

Pharmacology > Exam 2: Antibiotics-Quinolones, Metronidazole, Misc, AminoGlycosides > Flashcards

Flashcards in Exam 2: Antibiotics-Quinolones, Metronidazole, Misc, AminoGlycosides Deck (20)
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1
Q

What class of antibiotics is our BIG GUN? Cleans out the garage by BLOWING it up

A

Quniolones

2
Q

What is the mechanism of action of Quinolones? Spectrum? Cidal/Static?

A

Inhibit DNA synthesis during bacterial replication..broad spectrum, bacteriocidal

3
Q

What is the sub category of Quinolones?

A

FluoroQuniolones

4
Q

What is the primary antibiotic given to Anthrax exposure?

A

CiproFloxacin

5
Q

What is the target for Ciprofloxaxin?

A

DNA Topoisomerases (busts replication, transcription, and repair. BOOM BITCH)

6
Q

What is a major oral adverse event of Quniolones?

A

Xerostomia!

7
Q

Qunolones are the first drug to have this type of adverse effect…

A

CNS! Dizziness, headache, vertigo

8
Q

What class am I? Medical = to treat resistant organisms

A

Quniolones

9
Q

What are the two Quniolones that we need to know?

A

CiproFloxacin and LevoFloxacin

10
Q

What class of drugs is antibiotic, amebicide, antiprotozoal Bactericidal, Broad spectrum, and is a Synthetic drug??

A

Metro-Ni-Da-Zole

11
Q

Metronidazole: Used to supplement other antibiotics when _________ condition is not responding…Broadens spectrum of kill when used in combination….Not susceptible to ________…Very effective against periodontal pathogens*

A

periodontal…penicllinase

12
Q

KNOW THESE!! What are the 4 adverse effects of MetroNiDazole?

A

1.Hematopoietic System 2.Metallic Taste 3.Circumoral Paresthesia 4.Oral Ulcerations

13
Q

Which drug do you ESPECIALLY want to avoid alcohol when using? SO NO EtOH MOUTHWASH!!!! It is a “_______” like reaction.

A

Metro-ni-dazole..”disulfram” like rxn

14
Q

What is the mechanism of action of Vancomycin?

A

Inhibits bacterial cell wall synthesis (diff from penicillin tho)

15
Q

Vancomycin (Vancocin) “________” antibiotic, Inhibits _______ synthesis, but with a different mechanism than the penicillins…Used for ______ staph infections, strep infections, enterococcal infections…Used to treat antibiotic-induced pseudomembranous colitis caused by _____.



A

“miscellaneous”…bacterial cell wall..resistant…C/ Diff

16
Q

Who am I? Was considered one of the last lines of antibiotic defense…Now, many cases of vancomycin-resistant bacteria: especially enterococci…Prompted the development of new classes of antibiotics in U.S.

A

Vancomycin

17
Q

What class am I? These are products of actinomycetes (soil bacteria) or semi- synthetic derivatives of the natural products.

A

Aminoglycosides

18
Q

What is the mechanism of action for Aminoglycosides?

A

Binds to 30s ribosome

19
Q

What word does aminoglycosides end in?

A

mycin….dont confuse

20
Q

What is the main side effect of aminoglycosides?

A

Ototoxic-hearing loss