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Flashcards in Exam 1: PharmacoKinetics Deck (84)
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1

_________ is the study of how a drug enters the body, circulates within the body, is changed by the body, and leaves the body.

Pharmacokinetics

2

What are the 4 major steps of drug movement in the body?

1.Absorption 2.Distribution 3.Metabolism 4.Excretion

3

Determing a drugs ability to exert an effect: The ______ of drug that is able to pass through a cell membrane.... The ____ at which a drug moves through the body

amount...rate

4

________ = the more, the easier that the drug will cross

Lipid Solubility

5

Degree of ionization (charge) = charged molecules cannot cross (must use _____/_____).

pores/channels

6

______ sized molecules cross more easily.

Smaller

7

_____ of the drug molecule = molecules can “contort” to fit through the membrane

Shape

8

_______ = small molecules that are water- soluble pass through membrane pores by the bulk flow of water

Filtration

9

_______ transport = large, ionized water-soluble drugs require a more complex mechanism than simple diffusion

Specialized

10

________ = drug forms a complex with a component of cell membrane on one side; complex is carried through membrane; drug is released on inside

Facilitated diffusion

11

_______ are engulfed by cell membrane and are released unchanged in cytoplasm (endocytosis)

vitamins!

12

Movement of glucose across cell membranes is _______ by insulin

facilitated

13

__________ = movement of drug molecules across biologic membranes against both a concentration and an electrochemical gradient...Requires _____

Active transport....ATP

14

What are the 3 influences on the RATE a drug is moved across the membrane?

1.Physiochemical factors (size, charge, etc) 2.Solubility 3.Route of administration

15

_______ = drugs given by this route are placed directly into the gastrointestinal tract...THERE ARE ONLY 2 WAYS: ______ & ______

Enteral....Oral & Rectal

16

________= administration that bypasses the gastrointestinal tract and includes various injection routes, inhalation and topical drug administration.

Par-enteral

17

Which route of drug administration is the cheapest, easiest, and most conveneient?

Enteral-Oral route

18

Liquid pills are absorbed more ______ then regular tablets.

quickly

19

A down side to recall route drugs are poorly or irregularly _______ from rectum. Poor patient _______, so its mainly used on ______.

absorbed...compliance...babies

20

Inhalation is a _____ way to access the circulation and it can be both ______ and systemic.

rapid...local

21

What is the MOST RAPID route for drug response, and it produces a _______ response.

IntraVenous... Predictable

22

IntraMuscular route allows for a _______ effect of the drug (absorbed more slowly)

sustained

23

Topical Route: can be either _____ or ______ in effect, depending on dose.

local or systemic

24

What is the newest route of drug administration in dentistry?

subgingival! (in pocket)

25

What is the official title for the route we use to give a IA block?

Subcutaneous

26

In a sublingual route the drug is _____ absorbed.

rapidly

27

What is the most concentrated drug delivery vehicle?

Transdermal (pouch)

28

The _______ route is an injection of solutions into the spinal sub-arachnoid space?

IntraTheCal

29

The _______ route places fluid into the peritoneal cavity for exchange of substances.

IntraPeritoneal Route (form of dialysis)

30

Drug _______ is the movement of the drug from its site of administration into the plasma.

absorption