Flashcards in Exam 1: PharmacoKinetics Deck (84)
_________ is the study of how a drug enters the body, circulates within the body, is changed by the body, and leaves the body.
What are the 4 major steps of drug movement in the body?
1.Absorption 2.Distribution 3.Metabolism 4.Excretion
Determing a drugs ability to exert an effect: The ______ of drug that is able to pass through a cell membrane.... The ____ at which a drug moves through the body
________ = the more, the easier that the drug will cross
Degree of ionization (charge) = charged molecules cannot cross (must use _____/_____).
______ sized molecules cross more easily.
_____ of the drug molecule = molecules can “contort” to fit through the membrane
_______ = small molecules that are water- soluble pass through membrane pores by the bulk flow of water
_______ transport = large, ionized water-soluble drugs require a more complex mechanism than simple diffusion
________ = drug forms a complex with a component of cell membrane on one side; complex is carried through membrane; drug is released on inside
_______ are engulfed by cell membrane and are released unchanged in cytoplasm (endocytosis)
Movement of glucose across cell membranes is _______ by insulin
__________ = movement of drug molecules across biologic membranes against both a concentration and an electrochemical gradient...Requires _____
What are the 3 influences on the RATE a drug is moved across the membrane?
1.Physiochemical factors (size, charge, etc) 2.Solubility 3.Route of administration
_______ = drugs given by this route are placed directly into the gastrointestinal tract...THERE ARE ONLY 2 WAYS: ______ & ______
Enteral....Oral & Rectal
________= administration that bypasses the gastrointestinal tract and includes various injection routes, inhalation and topical drug administration.
Which route of drug administration is the cheapest, easiest, and most conveneient?
Liquid pills are absorbed more ______ then regular tablets.
A down side to recall route drugs are poorly or irregularly _______ from rectum. Poor patient _______, so its mainly used on ______.
Inhalation is a _____ way to access the circulation and it can be both ______ and systemic.
What is the MOST RAPID route for drug response, and it produces a _______ response.
IntraMuscular route allows for a _______ effect of the drug (absorbed more slowly)
Topical Route: can be either _____ or ______ in effect, depending on dose.
local or systemic
What is the newest route of drug administration in dentistry?
subgingival! (in pocket)
What is the official title for the route we use to give a IA block?
In a sublingual route the drug is _____ absorbed.
What is the most concentrated drug delivery vehicle?
The _______ route is an injection of solutions into the spinal sub-arachnoid space?
The _______ route places fluid into the peritoneal cavity for exchange of substances.
IntraPeritoneal Route (form of dialysis)