Exam 5-Stimulants Flashcards Preview

Pharmacology > Exam 5-Stimulants > Flashcards

Flashcards in Exam 5-Stimulants Deck (56)
Loading flashcards...
1

What are the two main systems that are indicated for the use of stimulants?

CNS and respiratory systems...stimulants are primarily used as an antidote for depression in these systems..."ANALEPTIC"

2

Which class of stimulants are primarily used for asthma to reverse respiratory depression (bronchodilators)?

Xanthenes

3

Which class of stimulants are primarily for hyperkinetic children?

Centrally acting sympatho-mimetics (amphetamine)

4

Which class of stimulant is primarily used for diagnostic purposes?

convulsants

5

What are the three examples of Xanthenes? (thank the lord Jesus for these!)

aminophylline, theophylline, and caffeine

6

I love this shit- 12 oz can of Coke = ____ mg caffeine

50 mg

7

I love this shit- 1 cup coffee = ___ mg caffeine

85 mg

8

I love this shit- 1 cup tea = ___ mg caffeine + _______

50 mg caffeine + theophylline!

9

___-____ mg of caffeine or theophylline is needed to increase cortical activity (1 to 4 cups of coffee) (while the OTC pill forms have ____-____ mg of caffeine

50-200 mg...100-200 mg

10

Stimulant potency....Cerebral cortex = ___-___ mg (small dose produces effect = more potent)...Brain stem = >___ mg (greater dose required)...Spinal cord = _____ mg (highest dose required) = can lead to convulsions, SHAKINESS

50-200 mg....250 mg...1000 mg

11

Pharm effects of stimulants-Blood vessel _____...especially _____ and ______ blood vessels

dilation...coronary and peripheral

12

Pharm effects of stimulants- _____ receptor effect

beta-2

13

Caffeine ________ peripheral resistance and can therefore cause _____tension, but guess what _______ more potent than caffeine!! WHAA

decreases...hypotension... theophylline

14

HMMMMM while Caffeine dilates the peripheral and coronary vessels, it CONSTRICTS _______ blood vessels which is great for treating a _______!!

cerebral...headache!!!

15

Xanthenes also cause cardiac muscle stimulation via _____ receptors.. the overall effect is ______ cardiac output

beta 1...increased

16

Did you know? theophylline = inhibits _____ which increases perfusion

ADH

17

GOOD TO KNOW! Caffeine will cause arrhythmias in someone who is at risk for them, but does not produce them in a normal heart *

arrhythmias

18

Xanthene Pharm Effects- the Beta-2 effect. these drugs will _______ smooth muscle and will therefore broncho_______

relax...bronchoDilate

19

Xanthene Pharm Effects-Which xanthene is such a potent bronchodilator tha it is used to treat asthma?

Theophylline

20

Xanthene Pharm Effects- the ONLY instance where caffeine was more influential then theophylline is ______ contraction. This can lead to _____ in the neck.

skeletal muscle contraction..tension

21

Xanthene Pharm Effects- _______ by increasing GFR, inhibiting ADH and increasing perfusion to kidney

Diuresis

22

Xanthene Pharm Effects- _______ by increasing GFR, inhibiting ADH and increasing perfusion to kidney

Diuresis

23

The only two cases where caffeine is equal to or greater than in potency/efficacy of theophylline is _____ and _____.

CNS (equal), Skeletal Muscle (greater than)

24

The only two cases where caffeine is equal to or greater than in potency/efficacy of theophylline is _____ and _____.

CNS (equal), Skeletal Muscle (greater than)

25

Adverse reactions of Xanthenes-_____tenison and _____ forming.

hypotension and habit forming

26

Adverse reactions of Xanthenes-_____tenison and _____ forming.

hypotension and habit forming

27

Caffeine toxicity NOOOOO! ____ mg required to produce toxicity.

300 mg

28

INTERESTING! _____ or more cups of caffeine daily produces physical dependence (_____ mg /day > 6 cups of coffee = 510 mg)

5...600 mg

29

Caffeine- ______ syndrome begins within 24 hours of discontinuance and you can develop ______ to the effects. NOOOOOOO

withdrawl...tolerance

30

Therapeutic uses of Xanthenes- what in the lungs? What in the CNS?

Asthma and wakefulness