Exam 3 Antivirals Flashcards Preview

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Flashcards in Exam 3 Antivirals Deck (14):
1

4 mechanisms of action in antiviral drugs

1. alter uncoating of virus
2. polymerase inhibitors
3. inhibit viral protein synthesis
4. target reverse transcriptase which blocks viral replication

2

name the 6 classes of antiretroviral drugs used to manage HIV

1. Nucleoside reverse transcriptase inhibitors
2. protease inhibitors
3. non-nucleoside reverse transcriptase inhibitors
4. fusion protien inhibitors
5. integrase inhibitors
6. nucleotide reverse transcriptase inhibitors

3

Which class of drug has no effect on cells that already have HIV?

Nucleoside reverse transcriptase inhibitors (drug is integrated into DNA polymerase to that synthesis of viral DNA is terminated -> inhibits viral enzyme reverse transcriptase = blocks viral replication)

4

Which class of drug interferes with action of HIV infected cells?

Protease inhibitors

5

What class of drug does not require bioactivation (resistance develops quickly if used alone)

Non-Nucleoside reverse transcriptase inhibitors

6

Which class of drug prevents integration of proviral gene into DNA?

Integrase inhibitor

7

Name 8 nucleoside reverse transcriptase inhibitors

1. abacavir (Ziagen)
2. tenofovir (Viread)
3. didanosine (Videx)
4. emtricitabine (Emtriva)
5. lamivudine (Epivir)
6. stavudine (Zerit)
7. zalcitabine (Hivid)
8. zidovudine (Retrovir) = AZT

8

MOA for Retrovir

inhibits HIV synthesis and reduces morbidity/mortality from AIDS

9

4 oral side effects of Retrovir

1. altered taste
2. tongue edema
3. bleeding gingiva
4. mouth ulcers

10

Retrovir potentiates toxicity (decreases metabolism) with which 3 drugs?

1. acetaminophen
2. aspirin
3. indomethacin
(NSAIDS)

11

4 side effects of Retrovir

1. toxic
2. bone marrow
3. depression
4. nausea

12

Goals of medication therapy for patients with HIV infections:
1. Target structural and functional differences between ____ and ___ proteins. Tx of HIV requires _____. _____ are used to improve effect
2. Prevent ____ infections

viral
human
HAART (highly active antiretroviral therapy)
Cocktails
Opportunistic

13

What is the antiviral triple cocktail made up of?

2 nucleoside reverse transcriptase inhibitors
1 protease inhibitor

14

Name 8 opportunistic infections and their treatment

1. pneumocysis carinii - sulfa drugs
2. viral infections - acyclovir, ganciclovir, foscarnet
3. Candidiasis - fluconazole ketoconazole
4. cryptococcus & histoplasmosis - amphotericin B
5. TB - isoniazid, rifampin
6. CMV - ganciclovir
7. EBV - acyclovir
8. linear gingival erythema and NUP