Flashcards in Exam 4 Drugs for smoking cessation Deck (29):
3 types of drugs used for smoking cessation
1. nicotine replacement therapy
2. bupropion (Zyban)
3. varenicline (Chantix)
Nicotine functions as what?
How is nicotine replacement therapy set up?
Pts must completely stop smoking prior to therapy
gum,lozenge, inhaler, nasal spray OTC
step down approach for 7-12 weeks
dosing gradually tapers down to wean off nicotine
designed to decrease cravings
Why must you quit smoking before starting nicotine replacement therapy?
nicotine raises cardio risk so cant smoke at the same time
what else is bupripion (Zyban) used for?
dopamine reuptake inhibitor = antidepressant (Wellbutrin)
Why should you avoid alcohol when taking bupripion?
risk for seizures
How long is the course of tx for bupripion?
Whats is the risk when used concurrent with patch?
emergent hypertension - monitor BP
varenicline (Chantix) is the newest smoking cessation drug, it is a partial neuronal ____-_ __ nicotinic receptor agonist and occupies nicotine receptor sites in the brain
How does varenicline work?
prevents nicotine stimulation of mesolimbic dopamine system and stimulates dopamine activity but to a lesser extent than nicotine which results in decreased craving and withdrawal symptoms
2 oral side effects of varenicline (Chantix)
2. taste alteration
5 general side effects of varenicline (Chantix) - risks increased when used with nicotine replacement therapy
3. abnormal dreams
5. new reports of suicidal thoughts/ aggressive behavior / adverse cardiac events
What percent of smoking women want to quit?
Average number of quit attempts?
Name of the program to help assist dental professionals with helping patients to quit smoking
Ask, Advise, Refer - 7-12 weeks long tx
What affect doe nicotine have on bone?
stimulates IL-6 which increase osteoclastic resorption and decreases estrogen protective effects on bone
___% of inhaled smoke is absorbed in oral cavity
30% - cancer risk, higher in females
4 desired effects of nicotine
1. increased alertness
2. muscle relaxation
3. facilitation of concentration and memory
4. decreased appetite
8 harmful effects of nicotine
3. increased pulse rate
4. induces nausea/vomiting
7. lung cancer
8. oral cancer
average age of initiation of smoking
nicotine causes lower estrogen levels which has what 4 effects
1. low birth weight babies
2. pregnancy complications
3. early menopause
smoking ___ age of first heart attack and ___ risk for heart attack
periodontal disease can be caused by smoking because...
nicotine stimulates IL-6 which increase osteoclastic resorption, nicotine decreases estrogen-protective effects on bone
name 10 cancer besides lung that can be due to smoking
10. acute myeloid leukemia
____ additives are approved by the US government in the manufacturing of cigarettes
599 (when burned, cigarette smoke contains over 4000 chemicals, 40 known carcinogens - carbon monoxide, nitrogen oxides, hydrogen cyanide and ammonia)
cigarette smoking = major cause of ___ cancer
esophageal (mouth cancers increase among people who smoke pipes and cigars)
8 notable chemicals in cigarettes
2. hydrogen cyanide
7. carbon monoxide
1 cigarette has how much nicotine?
8-9 mg (cigar 100-200 mg some up to 400 mg)