Flashcards in Exam 3 Heavy metals Deck (22):
MOA of heavy metals: All metals produce ___ in animals and humans, form stable coordination complexes with a variety of ____, disrupt ___ and ____ processes, loss of ___ production, loss of ion ____, and potential _____.
enzymatic and transport
What sign of arsenic poisoning is used in the diagnosis?
garlic breath (other signs/symptoms: dermatological, vasodilation, vomiting, peripheral neuropathies, organ encephalopathy, headache, coma, teratogenic, and carcinogenic)
Acute exposure to mercury VAPOR will cause what 5 things?
1. CNS effects
2. psychotic reactions
5. suicidal tendency
Acute exposure to mercury at levels of 1.1 to 44 mg will result in what 5 things?
1. chest pain
5. impairment of pulmonary function
6. intersitial pneumonia
Chronic exposure to low levels of mercury vapor will cause what 3 things?
2. impaired cognitive skills
3. sleep disturbances
What type of mercury can be corrosive to oral cavity/gut and cause kidney damage?
inorganic mercury - found in amalgam
Long term exposure of what drug will cause nephropathy, abdominal pain, delayed puberty in girls, reduced cognitive capacity, and schizophrenia?
What oral manifestation is common with lead poisoning in children?
dark gray lines visible in teeth along the gingiva
Side effects of what poison are dermatitis, metallic taste in mouth, proteinuria, GI, aplastic anemia?
Side effects of what poison are in small doses headache, dizziness, and depression, and in large doses violent and frequent vomiting, diarrhea, muscle pain, and death with in days
____: become absorbed in CV system and deposited into tissue, turn skin blue/grey (not permanent)
What acute poisoning causes pulmonary problems and chronicly causes emphysema, COPD, and cancer?
Cadmium ( antidote can cause renal toxicity)
What poisoning causes GI, pneumonitis, convolusions, coma, and liver damage?
What poisoning causes dermatitis, nasal and respiratory cancer?
antidote for iron/aluminum poisioning
Deferoxamine - complexes with trivalent ions (ferric ions) to form ferrioxamine which is removed by kidneys
antidote for nickel poisioning
antidote for mercury poisoning
antidote for lead/cadmium poisoning
calcium disodium edetate (EDTA)
antidote for gold/mercury poisoning
penicillamine - used long term to clear bone, skin, and keratinized tissues of arsenic antimony
antidote for arsenic/antimony/gold/mercury/lead/cadmium poisoning
Dimercaprol (BAL, dithioglycerol)
MOA for dimercaprol
sulfhydryl group + ions of heavy metal to form relatively stable nontoxic soluble chelates that are excreted in urine