Excitatory and Inhibitory Neurotransmission Flashcards Preview

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Flashcards in Excitatory and Inhibitory Neurotransmission Deck (17)
1

What is the typical resting membrane potential for a neuron?

-70mV

2

Is it the depolarization of repolarization of neurones that causes the release of neurotransmitter substances?

Depolarization

3

Does opening of sodium channels cause excitation or inhibition?

Excitation. Sodium flows inwards and causes depolarizaion

4

Give an example of a drug that is a Na+ channel antagonist

Lidocaine

5

At the synapse what channel is opened in response to depolarization?

Voltage activated calcium channels

6

At the synapse, what does the influx of calcium cause?

Exocytosis of synaptic vesicle contents.

7

Where are ionotropic receptors most often found?

Skeletal muscle

8

In glutamate mostly an excitatory or inhibitory neurotransmitter?

Excitatory

9

What is an ionotropic receptor?

The receptor is an integral component of the molecules that forms the channel in controls (direct gating)

10

What is a metabotropic receptor?

The receptor and the channel is controls are distinct; indirect gating.

11

Do NMDA receptors have a high or low permeability to Ca+?

High

12

Which receptor has a faster action; ionotropic or metabotopic?

Ionotropic

13

Which receptor acts as a synaptic modulator (slows down neurotransmitter release); ionotropic or metabotropic?

Metabotropic

14

Which receptor is a nicotinic receptor; ionotropic or metabotopic?

ionotropic

15

Which receptor is a G protein coupled receptor; ionotropic or metabotropic?

Metabotropic

16

What is the main excitatory neurotransmitter?

Glutamate

17

What is the major inhibitory neurotransmitter?

GABA