Eyes Flashcards

(83 cards)

1
Q

How do images form on the retina?

A

Light waves from object bent by cornea + lens (refraction of light)
Closer the object thicker the lens

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2
Q

How does the eye accommodate for distances?

Ie (from distant to close)

A

Lens changes shape
>(thicker + more spherical )
Pupils constrict
Eyes converge

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3
Q

How does the lens change shape?

A

Ciliary muscle contracts making ciliary body bulge
Space in middle decreases
Suspensory ligaments become lax
Lens no longer stretched, becomes thicker

Opposite if close to distant (muscle relaxes etc)

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4
Q

What effect do the pupils changing dilation have in accommodation?

A
By constricting allows only the rays from the object into the eye, or allows more rays in if dilate
Pupillary constrictor (sphincter pupillae) is a concentric muscle around the border of the pupil which gets parasympathetic innervation.
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5
Q

What are the types of refractive errors?

A

Myopia
Hyeropia
Astigmatism
Presbyopia

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6
Q

What is myopia?

A

Short sightedness
Where image is formed in front of the retina
Eyeball often too long
Bending power too much for the eye
When object brought closer, rays are divergent and need to be bent more, thus formed on the retina

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7
Q

What are the symptoms of myopia in children?

A

Headaches, unable to see whiteboard
Can form divergent squint
Toddlers may lose interest in sports/people - more interest in books/pictures

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8
Q

How do you correct myopia?

A

Bending power must be decreased
Bi-concave lenses - spectackes/contact lenses
Laser surgery

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9
Q

What is hyperopia?

A

Long-sightedness
Bending power not great enough, image formed behind retina
Eyeball often too short, cannot see nearby
Uses muscles to thicken lens for far away objects
Cannot thicken past a point, and then cannot see clearly

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10
Q

What are teh symptoms of hyperopia?

A

Often eyestrain when reading/on computer
Convergent squint in children - needs immediate correction
May have lazy eye

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11
Q

How do you correct hyperopia?

A

Can treat with biconvex lenses/glasses

+ surgery

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12
Q

What is astigmatism?

A

Surface has different curvatures
Therefore bending of light never the same as in the other axis so image hazy
Laser eye surgery, or lenses only curved in one axis
>Special contact lenses called toric lenses

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13
Q

What is presbyopia?

A

Where lens gets less mobile/elastic
Not as able to change shape, so nearby objects difficult
Treat with biconvex glasses

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14
Q

What is phototransduction?

A

Conversion of light energy into electrochemical response by photoreceptors (rods/cones)
Phototransduced rods/cones activate optic neurones (generate AP)
Photoreceptors (contained in lamellae part of rod/cone) have different wavelengths
Send signals when specific sensitivity reached

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15
Q

What pigment is responsible for vision?

A

Opsin + 11-cis Retinal

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16
Q

What is 11-cis retinal?

A

chromophore nesting in the opsin - formed from dietary Vitamin-A.
When light falls on 11-cis retinal, isomerises into transretinal - elongates and won’t fit into opsin, so rhodopsin splits resulting in bleaching of visual purple

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17
Q

What is the phototransduction cascade?

A

Rhodopsin is activated
Leads to sodium channels closing
Relative hyperpolarisation of photoreceptor cell
Transmitted by a flux of calcium ions, ultimately stimulates retinal cell

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18
Q

How is rhodopsin regenerated?

A

Trans retinol converted to 11-cis rol, converted to 11-cis retinal
Bi product of retinyl esters, and so need continous vitamin A in diet

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19
Q

Why is vitamin A important?

A

Without can lead to night blindness
Conjunctiva and corneal epithelium abnormal as needed for epithelium health
Clinical sign - bitots spots in conjunctiva - triangle of spec. Last a while
Corneal ulceration - dye to see extent
Cornea can “melt” leading to future opacification

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20
Q

What are the two types of ocular musclee + their function?

A

Intrinsic muscles - help control pupil diameter + alter lens curvature
Extrinsic - move eye

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21
Q

Where do the extrinsic muscles arise from?

A

Recti - from apex of orbit from annular ring
Superior oblique - posterior roof of orbit
Inferior oblique - anterior floor of orbit

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22
Q

What are the attachments of the levator papellae superiosus?

A

Roof of orbit

To upper eyelid

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23
Q

What are the attachments of the recti muscles?

A

Tendonous ring

Sclera anteriorly

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24
Q

What are the attachments of the superior oblique?

A
Lesser wing of sphenoid
Sclera posterioly (via trochlea)
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25
What are the attachments of the inferior oblique?
Medial part of orbit floor | Sclera posteriorly
26
Why do the extrinsic muscles move the eye in multiple directions?
Muscles attached along orbital axis, not optical so pull eyeball at an angle - each muscle will have more than one movement Oblique muscles attached to posterior part of sclera, so pull anterior part in opposite direction
27
What are the signs of the three main eye nerve palsies?
``` Third >Drooping eyelid >Eye can move only laterally (and slightly down) Fourth >Eye moving up when adducted Sixth >Eye being adducted >Unable to abduct ```
28
What is squint?
Misalignment of the eyes | Leads to two different images in brain
29
What are the two main types of squint?
Esotropia - manifest convergent squint | Exotropia - manifest divergent squint
30
What are the consequences of squint?
Amblyopia (lazy eye) - brain supresses images from one eye leading to poor vision in that eye without any pathology. Treat by stimulating "lazy" eye to work with eye patch in younger years Diplopia (double vision) - normally squint due to palsies
31
What is the visual pathway?
All fibres from eye pass through optic chiasma. The Temporal view (fibres near nasal) cross over to other side of the brain Therefore two optic tracts formed, one from right, one from left visual fields, and are on opposite side of brain to their field These fibres synapse at the lateral geniculate body of thalamus Form optic radiation, passes behind internal capsule to reach primary visual cortex in occipital lobe Thus the Right visual cortex sees the left half of the visual field and vice versa.
32
What visual defect would damage in the optic nerve lead to?
Blindness in one eye
33
What visual defect would damage in the middle of the optic chiasma lead to?
Both lateral view lost (bitemportal hemianopia)
34
What visual defect would damage in the optic tract lead to?
contralateral homonymous hemianopia | Blindness in both the right or the left field of visions in both eyes
35
How do you elicit the pupillary reflex?
Start in dimly lit room Pen torch in one eye, check that both pupils constrict Swing light to other side, both should remain constricted
36
What are the intrinisc eye muscles?
Ciliaris muscle in ciliary body Constrictor pupillae in iris at pupillary border Above innervated by parasympathetic CN III Dilator pupillae radially running muscle in iris Sympathetic innervation
37
Why does the pupillary response affect both eyes?
Impulses travel along optic nerve - optic chiasma - tract when light hits retina Some fibres do not enter the lateral geniculate body of thalmus Instead enter midbrain (where CN III is situated) Part of the IIIn nucleus is the edinger-westphal nucleus for these parasympathetic They go to the EWN on both sides, thus initiating response on each side
38
How does the pupillary response affect both eyes from the EWN?
Preganglionic parasympathetic fibres from EWN pass through IIIn into orbit Go to synapse in ciliary ganglion Postganglionic fibres go through short ciliary nerves to constrictor pupillae Constriction of both sides
39
What are the main pupil abnormalities?
Different sizes - anisocoria | Pupils may react abnormally to light
40
What is horner's syndrome?
Anisocoria due to damage to the sympathetic innervation to the pupil. You might also see ptosis (drooping of the eyelid) on the affected side Other signs – anhidrosis (loss of sweating on the affected side) Horner’s syndrome can occur due to disruption of sympathetic fibres at any point. An example would be Pancoast’s tumour of the lungs!
41
What can cause pupils to react abnormally to light?
Any abnormality of the afferent/efferent limb/ centre of reflex Diseases of the retina – > detachment/ degenerations or dystrophies Diseases of the optic nerve – such as in optic neuritis (frequently seen in MS) Diseases of the III cranial nerve (efferent limb)
42
What is a cataract and how common is it?
Lens opacification ~30% >65 Initially looks like spokes, then just becomes white
43
Why do cataracts develop?
UV rays enter eye, lens absorbs to stop harm to retina Lens damaged in process Older fibres never shed/regenerated Damaged lens fibres go opaque, cause cataract
44
How do you treat cataract?
Surgery only way Small insicion + lens capsule opened Cataractous lens removed by emulsification (pharmacoemulsification) Plastic lens placed in its stead Lens implant after cataract surgery – PCIOL = Posterior Chamber Intra Ocular Lens
45
What is glaucoma?
Raised intraocular pressure 2nd most common cuase of blindness Most commonly seen form of primary glaucoma is Primary Open Angle Glaucoma (POAG) ~1% population aged 40 – 89 Bilateral Patient can be asymptomatic for a long period of time Picked up on routine eye exams
46
What are the consequences of a raised IOP?
Pressure on nerve fibres cause them to die out and results in reduced visual field Optic disc appears pale, unhealthy and cupped Ultimately results in blindness
47
How do you treat primary open angle glaucoma?
``` Eye drops to reduced IOP Beta blockers Carbonic anhydrase inhibitors Prostaglandin analogues Laser trabeculopasty Trabeculectomy surgery ```
48
What is angle closure glaucoma?
``` Sudden onset and painful, with vision loss/blurring + headaches On examination >Red eye, cornea often o paque >Pupil mid-dilated >IOP severely raised ```
49
How does the angle close?
1 Functional block in the small eye - lens enlargement 2 mid dilated pupil - periphery of iris crowds around angle and outflow is obstructed 3 iris sticks to pupillary border prevents reaching anterior chamber. Leads to iris ballooning anteriorly and obstructing angle
50
How do you treat acute episodes of raised IOP?
Decrease IOP >IV infusion w/ or w/o oral therapy - carbonic anhydrase inhibitors Analgesic Constricor eye drops Steroid eye drops Iridotomy (laser) both eyes to bypass blockage
51
What is the difference between open and closed angle glaucoma?
In open angle the drainage through the tracbecular meshwork is blocked Which leads to GRADUAL increase in IOP Closed angle is where iris blocks angle so AH cannot drain Which leads to SUDDEN increase in IOP Red eye + pain Emergency
52
What are the types of corneal ulcer
Infectious - needs aggressive management to prevent spread/scarring Viral, bacterial, fungal Non-infectious - uclers due to trauma, corneal degeneration or dystropy
53
What are is a corneal dystrophies, how do they present?
``` Group of disesases that are >Bilateral, opacifying, non-inflammatory >Mostly genetic >Sometimes accumulation of substances Present in first-fourth decade Decreased vision One layer of cornea - spread to others ```
54
What is stromal corneal dystrophy?
Lattice (stromal) Autosomal dominant Depositation of amyloid material in corneal stroma Patient presents with eye irritation, pain, blurred vision Examination shows bilateral criss-crossing opacities in corneal stroma Treat by managing symptoms, corneal transplant
55
What is Fuch's endothelial corneal dystrophy?
Asymmetrical bilateral progressive odema of cornea Elderly Destruction/death of epithelium cells Eventually opacification Initially symptomatic, later corneal transplant
56
What are teh types of uveitits?
Anterior Intermediate Posterior
57
What is anterior uveitis?
iris inflammed - w/ or w/o ciliary body Leaks plasma and white blood cells into aqueous humour Seen in slit lamp examination as hazy anterior chamber + cells deposited in back of cornea Red, painful eye w/ vision loss
58
What is intermediate uveitis?
cilliary body inflammed Ciliary body inflammed leaks cells + proteins Leads to hazy vitreous humour Floaters/hazy vision
59
What is posterior uveitis?
choroid inflammed | Frequently spreads to retina, causing blurred vision
60
What are the causes of uveitis?
Isolated illness Non-infections auroimmune disease Infectious causes Systemic disease
61
What is conjunctivitis?
Self limiting bacterial/viral infection of conjunctiva Red, watery eyes, increased discharge No loss of vision as long as infection does not spread to cornea Treat with antibiotic eye drops if bacterial
62
What is fluroescein angiography?
To test if blood vessels getting enough blood flow Can point to macular degeneration or diabetic retinopathy Eye drops to dilate eyes Take pictures of inner eye Then inject fluorescein dye into vein in arm Take pictures as fluroescein moves through eye
63
What is optical choerance topography?
Non-invasive imaging test using light waves to take cross sections of retina
64
What can cause sudden painless loss of vision?
``` Central retinal vein occlusion Central retinal artery occlusion Ischaemic optic neuropathy Stroke Vitreous haemorrhage Retinal detachment Sudden discovery of pre-exisiting unilateral LoV ```
65
What are teh common causes of central retinal vein occlusion?
Hypertension Glaucoma Hyperviscosity Inflammation
66
What are the common causes of central retinal artery occlusion?
Embolis | Inflammation
67
What are the clinical features of ischaemic optic neuropathy?
``` Pain on eye movements Reduced vision Red desaturation Central scotoma Relative afferent pupil defect Swollen optic disc ```
68
What can cause a gradual painless loss of vision?
``` Cataract Refractive error Age-related macular degeneration Open angle glaucoma Diabetic retinopathy Hypertensive retinopathy Inherited retinal dystrophies Drug-induced retinopathy ```
69
What are age-related macular degeneration and its risk factors?
``` Common (10% >65, 30% >75) Progressive loss of central vision Risk factors >Age >Smoking >Poor diet ```
70
How does diabetic neuropathy present?
Cotton wool spots + exudates visible on retina Vascular abnormalities Maculopathy
71
What is cone dystrophy?
Inheritance Sporadic (90%) Dominant, X-linked recessive Photopic ERG reduced, scotopic normal
72
What drugs can induce a retinal dystrophy?
Anti-malarials Phenothiazines Tamoxifen
73
What are retinal dystophies?
Series of inherited conditions affecting photoreceptor functions leading to progressive loss of vision
74
How do you treat uveitis?
Treat infection if present Topical anti inflammatory Systemic steroid Systemic immunosuppresants
75
What are the features of orbital cellulitis?
``` Pain, redness, lid swelling Systemically unwell Double vision/limitation in EOEM Conjunctivitis/chemosis Exophthalmos Blurred vision ```
76
What are teh common causes of orbital cellulitis?
Sinusitis / dental infections | Haematological spread
77
What are the types of adnexal oncology?
Eyelid tumours Lacrimal drainage tumours Orbital tumours
78
How does squamous cell papilloma (of eye) present?
Pedunculated or sessile (broad-based) | Characteristic ‘raspberry’ texture
79
How does basal cell papilloma (of eye) present?
``` = Seborrhoeic keratosis Greasy, brown, flat, round/oval Similar texture to squamous cell papilloma ‘Stuck on’ appearance Unrelated to sun exposure ```
80
What is melanocytic naevus?
Composed of atypical melanocytes | Location of these melanocytes influences clinical appearance and potential for malignant transformation
81
What is pyogenic granuloma?
Fast growing, highly vascularised granuloma May follow surgery, infection, trauma Erythematous pedunculated mass Rx Excision
82
What is basal cell carcinoma of eye?
``` Features suggestive of BCC Slow, inexorable growth over months Usually non-pigmented, elevated, ulcerated Pearly, rolled, irregular border Telangiectasia Lack of tenderness ```
83
What is squamous cell carcinoma of the eye?
``` Sun damaged skin and pre-existing AK Scaly surface over a thick plaque Growth over weeks rather than months Metastatic risk of 3-10% Rx Excision ```