Final; Herpesvirus and Papillomavirus Flashcards Preview

SP14 Microbiology > Final; Herpesvirus and Papillomavirus > Flashcards

Flashcards in Final; Herpesvirus and Papillomavirus Deck (31):
1

What are the key characteristics of alphaherpesvirus

variable host range
short reproduction cycle
rapid spread in culture
efficient destruction of infected cells
capacity for latency

2

How is HSV-1 alphaherpesvirus transmitted

oral to oral
oral to genital
nearly 2/3 of adults are seropositive

3

How is HSV-2 alphaherpesvirus transmitted

genital to genital (some oral to genital)
prevalent with sexual activity
1/5 of adults are infected

4

Which cells does the HSV primarily infect

epithelial cells in the skin or mucosa; mucosa is more susceptible

5

What is the incubation time of HSV

2-14 days
typically 4-5 days

6

What are the symptoms of a HSV infection

flu-like; localized lesios
only 1/3 show symptoms with the asymptomatic still able to transmit

7

What is the duration of a HSV infection

8-12 days

8

How does HSV induce latency

the genome circularizes in stationary cells and stays as an episome in the nucleus
peripheral ganglia common
a stressful trigger can induce replication

9

What is required to combat the alphaherpes virus

cell mediated immune response

10

What strategies are used to prevent and treat alphaherpes infections

avoid contact during active herpes recurrence
Acylovir can be used to eliminate latent infections

11

What kind of host range does beta and gamma herpes virus have

restricted host range

12

What kind of reproductive cycle and progression does beta herepes have

longe reproductive cycle
sloe progression in cell culture

13

What does betaherpes do to the host cell

causes enlargement of infected cells; cytomeglia (CMV)

14

Where can you find the latent infection of beta herpes

in a variety of cells

15

What does gamma herpes target and causes what

T and B lymphocytes
lytic infections, latency in lymphoid tissue
Epstein Barr virus (EBV)

16

This virus is associated with carcinoma

EBV

17

This is a common childhood cancer in Africa caused by EBV

Burkett's lymphoma

18

This is caused by EBV and can cause nodular sclerosing, mixed cellularity, or lymphocyte depletion

Hodgkin's lymphoma

19

What are the three methods of immune evasion that beta/gamma uses

intrinsic
innate
adaptive

20

This persists in hematopoietic progenitor cells and macrophages; is a chronic persistent infection; controlled by healthy, active immune system

CMV

21

This persists in the genome of B cells, it ensures B cell proliferation and its genome replication

EBV

22

How are beta/gamma herpes treated

usually self-limiting
antivirals
immunoprophylaxis
there is no vaccine

23

What is the genome type of HPV

circular dsDNA

24

What is the virion of HPV

non-enveloped

25

How is HPV transmitted

direct skin to skin contact; it gains access through skin abrasions

26

How does HPV replicate in the skin

establish infection in basal layer
needs cells polymerase
virus is produced in differentiating cells
non-lytpic, virus spread with dead skin shedding

27

What makes HPV so hard to get rid of

its very hearty to environmental stress, allows transmission through fomites

28

What are the symptoms of HPV

warts at site of infection; 50% regress on own

29

What is the rare symptom of HPV

respiratory papillomatosis; can be lethal

30

What causes HPV to proliferate into cervical cancer

E7 blocks Rb = continued cell proliferation
E6 blocks p53 tumor supressor pathway
actual path unknown

31

What are the treatments/prevention strategies of HPV

ablative treatment (laser, surgery, chemicals, etc.)
vaccination; Gardisil