EX1 Antigen Processing/Presentation - Stiner

Question 1

CD8 cells recognize MHC class (I or II)

Answer 1

MHC class I

Question 2

CD4 cells recognize MHC class (I or II)

Answer 2

MHC class II

Question 3

______ _____ is the bridge between antigen recognition and the ignition of a full-blown immune response

Answer 3

antigen presentation

Question 4

Antigen presentation enables T cell-mediated _______ or augments antibody production by ______

Answer 4

killing

B cells

Question 5

Antigen presentation is ______ ______, allowing the deployments of appropriate immune responses under different conditions

Answer 5

context dependent

Question 6

Antigen recognition without antigen presentation can result in ________, this minimize the chances of _________ activity

Answer 6

tolerance

autoimmune

Question 7

Antigen presentation is modulated by _______ _______

Answer 7

co-stimulatory molecules

Question 8

Successful antigen presentation results in activation of _______

Answer 8

T cells

Question 9

What are the three main antigen presenting cells (APCs)

Answer 9

dendritic cels
macrophages
B cells

Question 10

All nucleated cells can present endogenous antigens in association with MHC class (I or II) molecules

Answer 10

MHC class I

Question 11

Pathway 1 of antigen processing involves (endogenous/exogenous) antigens

Answer 11

exogenous

Question 12

Pathway 2 of antigen processing involves (endogenous/exogenous) antigens

Answer 12

endogenous

Question 13

In this pathway of antigen processing the antigens are digested to small peptides and presented to CD8 cells via MHC class I; uses ubiquitin

Answer 13

Pathway 2 (cytosolic pathway)

Question 14

In this pathway of antigen processing the antigens are taken into the cell, small peptides are generated and presented to CD4 cells via MHC class II

Answer 14

Pathway 1 (endocytic pathway)

Question 15

The processes by which antigens are digested and placed on the cell surface with correct MHC molecules

Answer 15

antigen processing

Question 16

The invariant chain/CLIP of MHC class II processing does what?

Answer 16

keeps the MHC from binding with anything while it is forming/traveling

Question 17

Both class I and class II MHCs are formed in the ______

Answer 17

rough endoplasmic reticulum (RER)

Question 18

MHC class (I or II) makes use of an endocytic compartment containing the antigen to be presented

Answer 18

MHC class II

Question 19

MHC class (I or II) contains α1, α2, α3, and a β2 component

Answer 19

MHC class I

Question 20

MHC class (I or II) contains an α1, α2, β1, and a β2 component

Answer 20

MHC class II

Question 21

MHC haplotypes can influence three things like…

Answer 21

how an individual responds to certain pathogens
susceptibility to certain diseases
transplant success

Question 22

True or False

MHC genes are highly polymorphic

Answer 22

True; roughly 10^13 different combinations; the alleles are co-dominantly expressed

Question 23

True or False

MHC molecules have a broad specificity for peptides

Answer 23

True; many different peptides can bind within MHC binding clefts

Question 24

True or False

Peptides associated with MHC have a rapid on and rapid off rate

Answer 24

False; they have a slow on and off rate

Question 25

True or False | MHC molecules do discriminate from self and foreign peptides

Answer 25

False; they do not discriminate

Question 26

MHC ________ allows individual T cells to recognize foreign antigens displayed on the surface on an individual APC; allowing recognition of self or non-slef

Answer 26

MHC restriction

Question 27

True or False In order for the antigen to be properly presented the T-cell receptor (TCR) must engage the MHC molecule and other co-stimulatory molecules

Answer 27

True

Question 28

The main secondary signals of MHC/TCR recognition are ______ and _____

Answer 28

CD28 (on T cell) | B7 (on APC)

Question 29

Which T cell recognizes cytosolic proteins

Answer 29

CD8

Question 30

Which T cell recognizes extracellular/intravascular pathogens

Answer 30

CD4

Question 31

____ and ____ are non-covalently associated to the TCR and they are required for antigen recognition and signaling

Answer 31

CD3 and ζ (zeta)

Question 32

_______ competitively binds to B7; blocking signals from the TCR

Answer 32

CTLA-4

Question 33

True or False | You must have both the MHC and co-stimuntory molecule in orderer for the T cell to be activated

Answer 33

True

Question 34

What interleukin drives the development of Th1 cells

Answer 34

IL-12

Question 35

What interleukin drives the development of Th2 cells

Answer 35

IL-4

Question 36

Th (1 or 2) cells provide help for cell mediated immune responses

Answer 36

Th1

Question 37

This is an important Th1 cytokine

Answer 37

IFN-γ

Question 38

Th (1 or 2) cells provide help for humoral immune responses

Answer 38

Th2

Question 39

This is an important Th2 cytokine

Answer 39

IL-4