Flashcards in Ford Review Deck (116)
What are the four types of noncovalent interactions?
van der waals
Example of charge-charge interaction
Example of dipole interaction
selectivity filter of K+ channgel
Example of van Der Waals interactions
Example of hydrogen interactions
nuclei acid and base pairing/protein secondary structure
If pH< pKa what does that mean?
If pH> pKa what does that mean
If pH=pKa what does that mean?
just as likely to be protonated as deprotonated
what is the equation for pKa?
pKa= -logKa = [H+] [A-] / [HA]
What does Ka mean?
dissociation constant, predicts how likely an acid will donate a proton
What is the Henderson-Hasselbalch equation?
pH= pKa + log [A-] / [HA]
What happens when something is reduced?
gains electrons (H)
What happens when something is oxidized?
What amino acid preforms redox?
cystein (disulfide linkages are reductions)
What are the 3 important electron carriers in cellular metabolism and their reduced and oxidized forms?
What is equilibrium?
forward rate = reverse rate, no net formation or destruction
How does Le Chatlier fit into cellular metabolism?
it's how to drive an unfavorable reaction forward
-make pathway/use up products
-couple it to a favorable reaction like ATP hydrolysis
What is the gibs free energy equation?
deltaG= deltaH- TdeltaS
how does thermodynamics relate to protein folding?
change of entropy--protein folds, loses entropy
aqueous environment has more disorder
negative delta H
postive delta H
zero delta H
negative delta S
positive delta S
zero delta S
no net change in disorder
negative delta G
free energy released
positive delta G
free energy required
zero delta G
Give example of cooperative binding
hemoglobin binds oxygen cooperatively