Flashcards in Four Renal Autoregulators Deck (11):
What does aldosterone cause?
Na+ and H20 absorption
How does A2 work?
Binds G-proteins to cause intracellular signaling
What does A2 cause?
Decreased Renin secretion
Constrict mesangial cells decreasing GFR
Na+ reabsorption via Na-H exchanger in PCT
How does aldosterone increase Na+ reabsorption?
Increase genetic expression of apical Na+ channels and basolateral membrane Na/K ATPase
What does sympathetic innervation cause?
RAS cascade causing renin release, A2 vasoconstriction, and increase in Na+ and water reabsorption to increase pressure
How does sympathetic cause RAS?
Innervates granular cells to release renin
Two way ADH is released?
1.) Baroreceptors in the atrial walls detect low BP sending afferent signals to the hypothalamus causing release of ADH
2.) Hypothalamus osmoreceptors monitor concentration in the blood with increase osmolarity sends signals to posterior pituitary to release it
Mechanism ADH works through?
V1 receptors contraction of SM decreasing GFR
V2 in principal cells causing genomic expression of AQ2 and increasing transport of AQ2 receptors to membrane in the collecting ducts
How is ANP activated?
Atrial baroreceptors being stretched
What does ANP cause?
Decreases resorption of Na+ leaving it in the tubule