Renal Tubular Transport Mechanism II Flashcards Preview

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Flashcards in Renal Tubular Transport Mechanism II Deck (29):
1

Where does the largest amount of Na+ get reabsorbed?

Proximal convoluted tubule (70%)

2

Why does Na+ osmolality stay the same along the proximal tubule?

Water follows it wherever it goes

3

What pumps Na+ at the basolateral membrane?

Na+/Cl- ATPase pump

4

How does Na+ enter the apical membrane?

Downhill gradient

5

What is important to note about water movement in the PCT?

Water is reabsorbed via osmosis through aquaporins, this causes an increase in solute concentrations left behind allowing them to be reabsorbed down their gradients

6

What various ions pass via paracellular route?

Cl-
Ca2+
K+
Urea

7

What pumps glucose in the apical membrane?

SGLT2

8

What pumps glucose in the basolateral membrane?

GLUT2

9

What pumps HCO3- in the basolateral membrane?

Na+/HCO3- cotransporter

10

What way can Na+ move across the apical membrane TAL?

Solute symporters
Na-H exchanger
Na+ paracellular movement

11

Transepithelial electrochemical driving force in proximal tubule S1 and S3:

S1: -3mV
S3: +3mV
(stronger movement back in S3)

12

What does CFEX pump do?

Pumps chlorine in and bases out across apical membrane to tubule lumen where they are protonated and brought back into the cell

13

What does KCC pump do?

K+ Cl- cotransporter

14

What type of transport takes place in the thin loops of Henle?

Paracellular Na+

15

Where are the NKCC2 channels found?

Thick ascending limb

16

What does the NKCC2 do?

Apical membrane reabsorption of Na+/K+/2Cl-

17

What diuretic inhibits NKCC2?

Furosemide
Bumetanide

18

Where is the NCC (Na/Cl cotransporter) found?

Distal convoluted tubule

19

What diuretics block the NCC?

Thiazides

20

Where are ENaC receptors found?

Collecting tubule principal cells

21

What diuretics block ENaC?

Amiloride

22

What does ENaC do?

Pump Na+ across the apical membrane

23

What is the major absorber of chloride in the S3 cells?

CFEX

24

What does CFEX absorb?

Cl-formate/oxalate/HCO3 and OH exchanger

25

What pumps Cl- across the basolateral membrane in the S3 cells?

CFTR
KCC (K/Cl cotransporter)

26

Cl- reabsorption in the TAL apical membrane and basolateral:

Apical: Na/K/Cl cotransporter
Sodium/hydrogen exchanger
Basolateral: N/K pump
Cl- channel
Cl-HCO3 exchanger

27

Cl- reabsorption in the DCT apical and basolateral:

Apical: Sodium/Cl- (NC-cotransporter)
Basolateral: N/K pump
Chloride channel

28

Cl- transport in the collecting tubule principle cell:

Paracellular diffusion

29

Cl- transport in the collecting tubule beta-intercalated cells apical and basolateral:

Apical: N/HCO3- exchanger
Basolateral: Cl- channel