Transport Mg, Calcium, Phosphorus Flashcards Preview

Urinary Exam 1 > Transport Mg, Calcium, Phosphorus > Flashcards

Flashcards in Transport Mg, Calcium, Phosphorus Deck (14):
1

What catalyzes formation of urate?

Xanthine oxidase

2

What uptakes urate apical side?

URAT1
OAT4

3

What uptakes urate basolateral side?

OAT1/3
GLUT9

4

What drugs inhibit URAT1 and OAT4?

URAT1: Probenecid, benzbromarone, sulfinpyrazone
OAT4: Sulfinpyrazone

5

What drugs inhibit GLUT9 and OAT1/3?

Probenecid
Benzbromarone

6

Mechanism of gout?

Monosodium urate taken up by macrophages and they release IL-1Beta causing inflammation

7

What pumps phosphate across apical side

Na/Pi-IIa

8

What pumps phosphate across basolateral side

Na/Pi Type III

9

Apical Ca2 PCT/DCT

Calcium channels

10

Basolateral Ca2 PCT/DCT

Na/Ca exchange

11

Apical Ca2 TAL

Calcium channels

12

Basolateral Ca2 TAL

PMCA
Na/Ca

13

How does Mg move across the apical membrane

Ca2 sensing receptor senses Ca and transports Mg2 across

14

What protein is needed for Mg diffusion through tight junctions?

Paracellin-1 protein