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Flashcards in Fungicides Deck (21):
1

Fungicides generally have a high or low toxicity

low if properly used

2

Pentachlorophenol abbr.

PCP

3

PCP stands for

Pentachlorophenol

4

PCP use

- old wood preservative no longer in use

5

Source of PCP exposure

- vapor can penetrate intact skin
- inhalation from treated wood (sheds/ barns)
- licking wood
- contaminated feeds/ water

6

what is the most toxic route of exposure for PCP

- dermal
- especially for newborn animals

7

Properties of PCP

- chlorinated hydrocarbon
- very soluble in oils but not water unless in salt form
- volatile
- decomposed by bacteria

8

PCP toxicity

- acute= oral or dermal LD50 is 100-200 mg/ kg
- chronic= 40-70 mg/ kg

9

Factors that increase PCP toxicity

- High temperature
- oily vehicles
- previous exposure
- newborn
- hyperthyroidism

10

Factors that decrease PCP toxicity

- cold temperature
- antithyroid drugs
- body fat

11

PCP toxicokinetics

- Absorbed from GI tract, inhalation and intact skin
- distributed through body
- half life 2 days ish

12

How is PCP metabolized

- conjugates to glucuronic acid
- excreted as such or unchanged in urine

13

How long until PCP residues are not in the body

1 week

14

MOA of PCP

- uncouples oxphos and blocks/ decreases ATP
- increased oxygen demand
- leads to overheating, metabolic acidosis and dehydration

15

PCP clinical signs in acute cases

- may see no signs
- hyperthermia, tachycardia, dyspnea, cyanosis, seizure, collapse and death

16

PCP clinical signs in chronic toxicosis

- weight loss, decreased milk production, anemia, fetal malformations
- possible abortions

17

PCP lesions

- rapid rigor mortis
- irritation of membranes
- pulmonary congestion and edema
- dark blood
- hyperkeratosis

18

what to test for PCP poisoning

- blood and urine in live animal
- kidney and skin in dead animal

19

treatment for PCP

- no specific antidote
- detox with emetics, gastric lavage (5% sodium bicarb), activated charcoal, mineral oil, bath

20

Supportive therapy for PCP

- lowering body temp
- IV fluids
- antibiotics to prevent secondary infections

21

Prognosis for PCP

- fair if the animal survives 24 hours