Organic Arsenicals Flashcards Preview

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Flashcards in Organic Arsenicals Deck (17):
1

Use

- feed additives to improve weight gain and feed efficiency
- controls GI infections in swine and poultry

2

Which form is used in pigs

Arsanilic acid

3

Which form is used in poultry

Roxarsone

4

Source

- overdose or prolonged use

5

Properties

- Phenylarsonic acid derivatives
- Pentavalent state

6

Organic arsenic is more or less toxic than inorganic arsenic

less

7

Toxicity is enhanced by

dehydration, water deprivation and renal insufficiency

8

Toxicokinetics

- Small amount absorbed in GI tract
- distributed throughout body
- excreted unchanged in urine

9

MOA

- unknown
- causes peripheral nerve demyelination
- similar to vitamin B def.

10

Arsanilic acid in swine

- acute toxicosis in 3-5 days
- incoordination, ataxia, partial paralysis
- still have good appetite

11

blindness can occur with

arsanilic acid

12

Arsanilic CS in poultry

- anorexia, depression, coma and death

13

Roxarsone in swine

- sudden onset
- hyperexcitability
- tremors, collapse, coma
death
- NO blindness

14

Roxarsone in poultry

- incoordination and ataxia

15

Lesions in pigs

- possible erythema
- muscle atrophy (chronic)
- peripheral nerve and optic nerve degneration

16

Chemical analysis

- feed, liver and kidney

17

Treatment

- no specific antidote
- withdrawal of organic arsenicals
- supportive therapy
- recover in 2-4 weeks