Gastric, Intestinal, and Pancreatic Function Flashcards Preview

Chemistry Module 4 > Gastric, Intestinal, and Pancreatic Function > Flashcards

Flashcards in Gastric, Intestinal, and Pancreatic Function Deck (44):
1

Three functions of the stomach

1. Movement of food to the duodenum
2. Secretion of digestive enzymes, intrinsic factor, and hydrochloric acid
3. Partial digestion of proteins

2

Anatomical location of the stomach and names of three distinct zones

1. Fundus
2. Body
3. Antrum

3

Specific cell types in each zone of the stomach

Fundus: surface epithelial cells, mucus cells
Body: surface epithelial cells, mucus cells, parietal cells
Antrum: Mucous cells, G-cells, chief cells

4

Specific secretion(s) of surface cell epithelial

Produce mucus and shed and proliferate rapidly (every 3 days)

5

Specific secretion(s) of mucus cells

Secrete mucus

6

Specific secretion(s) of parietal cells

Hydrochloric acid and Intrinsic Factor

7

Specific secretion(s) of chief cells

Pepsinogen (that is converted in an acidic environment to pepsin)

8

Specific secretion(s) of G-cells

gastrin (gastrin stimulates the parietal cells to produce HCL)

9

Five functions of gastric hydrochloric acid

1. Converts pepsinogen to pepsin
2. Activates rennin (a milk curdling enzyme)
3. Combines with food proteins to form acid metaproteins which are more easily digested by pepsin
4. Prevent bacterial multiplication in the stomach
5. Prevents precipitation of ingested calcium so that soluble calcium may be absorbed

10

Four stimuli for gastrin release

1. When proteins, amino acids and calcium enter stomach
2. Vagus nerve is activated and releases acetylocholine
3. Catecholamines are circulating
4. Antrum is distended

11

Three phases of gastric secretion

1. Cephalic phases
2. Gastric phase
3. Intestinal phase

12

Cephalic phase stimuli and specific secretion produced in each phase

Vagus nerve, stimulated by site and smell, stimulates parietal cells to produce HCL and G-cells to produce gastrin

13

Gastric phase stimuli and specific secretion produced in each phase

- In the stomach, gastrin release stimulates parietal cells to produce more HCL
- Local antral distension stimulates further production of gastrin and therefore HCL
- Chief cells respond to acidic environment; pepsinogen is produced that is rapidly converted to pepsin at pH 3
- Chyme is produced (mucus-containing solution)

14

Intestinal phase stimuli and specific secretion produced in each phase

- Ingested food helps neutralize HCL
- Secretin is released, inhibiting gastrin-stimulated acid production and gastric motility
- Gastric secretions cease

15

Three functions of gastric fluid

1. Initiation of protein digestion
2. Physical and chemical preparation of ingested food for absorption
3. Secretion of intrinsic factor to promote Vit B12 absorption in the ileum

16

Four normal constituents of gastric secretions

1. Hydrochloric acid
2. Enzymes (pepsin (most important), salivary amylase, gastric lipase)
3. Mucus
4. Intrinsic factor

17

Three abnormal constituents of gastric fluid

1. Blood
2. Food
3. Organic acids

18

Appearance of fresh blood in the stomach

red

19

Appearance of blood that has remained in the stomach for a period of time

old blood is converted to hematin by the acidic pH and has a "coffee grounds" appearance

20

Four indications for gastric analysis

1. Aid in eval of patients with recurrent ulcer disease
2. Aid in diagnosis of Zollinger-Ellison syndrome by demonstrating a hypersecretory state
3. Determine if patient is able to secrete HCL at all (pernicious anemia)
4. Determine the completeness of vagotomy after gastric surgery

21

Specific diagnostic use of Basal Acid Output (BAO) for gastric function assessment

No stimulation after you fast and you measure if outputting acid; determine baseline pH

22

Specific diagnostic use of Maximum Acid Output (MAO) for gastric function assessment

Important in determining if the patient has low acidity or anacidity

23

Specific diagnostic use of Serum gastrin for gastric function assessment

Useful in diagnosis of the Zollinger-Ellison syndrome

24

Specific diagnostic use of Schilling test for gastric function assessment

Useful in the diagnosis of pernicious anemia

25

Specific diagnostic use of Hollander test for gastric function assessment

Useful in determining the completeness of vagotomy in peptic ulcer treatment; should not be increased in vagotomy

26

Recognize five lab findings in stomach cancer

1. Achlorhydria in gastric fluid
2. Anacidity or hypoacidity of gastric fluid
3. Blood ("coffee grounds" appearance) in gastric fluid
4. Blood in feces
5. Iron deficiency anemia due to blood loss

27

Recognize causes for gastric and peptic ulcers

1. Helicobacter pylori
2. Smoking
3. Caffeine
4. Alcohol
5. Stress
6.Physical stress
7. Acid and pepsin
8. Nonsteroidal anti-inflammatory drugs (NSAIDs)

28

List the specific cause for the Zollinger-Ellison

gastrinoma (a gastrin-secreting tumor of malignant cells in the duodenum or from a tumor in a non-beta islet cells of pancreas

29

List the four typical lab findings for Zollinger-Ellison syndrome

1. BAO > 10 mEq/hour
2. MAO usually less than 25% higher than BAO, ie, both are high all the time
3. Increased volume of secretion (160-800 mL/hour)
4. Serum gastrin levels two to twenty thousand times normal!!!

30

Cause of pernicious anemia

Gastric problems are caused by malfunctioning parietal cells, responsible for HCL production and secretion of intrinsic factor (IF)

31

Six typical lab findings in pernicious anemia

1. Anacidity
2. Decreased gastric secretion volume
3. Gastric atrophy
4. Increased serum gastrin (>200 pg/mL)
5. Macro-ovalocytes
6. Hypersegmented neutrophils

32

Functions of the duodenum

Has 6 major hormones to aid in digestion and protection of the intestinal lining; intraluminal hydrolysis of starch, proteins, and lipids

33

Functions of the illeum

- Absorption of Vitamin B12 and whatever products of digestion that were not absorbed by the jejunum
- Diffuse neuroendocrine system cells secrete gastrin, secretion, and cholecystokinin into the bloodstream

34

Functions of the large intestine

1. Absorption of water from the remaining indigestible food matters
2. Absorption of vitamins that are created by bacteria inhabiting the colon
3. Fecal compaction until it can be eliminated

35

Source of Cholecystokinin-pancreozymin (CCK-PZ)

Secreted by I cells of duodenum when digested proteins/fats enter duodenum and causes the:

36

Stimulus for Cholecystokinin-pancreozymin (CCK-PZ)

Secreted by I cells when protein and fats enter the duodenum

37

Three physiological effects Cholecystokinin-pancreozymin (CCK-PZ)

1. Pancreas to produce enzymes
2. Gall bladder to contract and empty contents
3. Sphincter of Oddi to relax to allow gall bladder and pancreatic contents to ender duodenum

38

Source of secretin

S cells both the duodenum and jejunum

39

Stimulus of secretin

released when acidified contents of stomach reach duodenum (pH < 5)

40

Two physiological effects of secretin

1. Acts in synergy with CCK for release of pancreatic enzymes
2. Simulates secretion of large amount of diluent pancreatic fluid rich in sodium bicarbonate

41

Physiological effects of gastric inhibitory peptide

stimulates insulin release and is responsible for rapid metabolism of an oral glucose load

42

Physiological effects of Vasoactive intestinal polypeptide

Causes relaxation of gut circular smooth muscle as well as smooth muscle in blood vessels, causing vasodilation. Also stimulates pancreatic secretion

43

Physiological effects of motilin

Stimulates the contraction of the smooth muscles of the GI tract and contracts the lower esophageal sphincter

44

Physiological effects of somatostatin

-Most potent inhibitor of endocrine secretions;
- inhibits release of GI and pancreatic hormones, as well as the release of GH and TSH;
- Inhibits actions of all these hormones on their target tissues