GI Histology III

Question 1

What does the Paneth cell do?

Answer 1

Secrete lysozymes to increase permeability of bacteria by degrading peptidoglycan coat
Defensins to increase membrane permeability to targer organisms
Tumor nercrosis factor alpha
May phagocytize some microorganisms and help regulate intestinal flora

Question 2

Toll like receptors

Answer 2

Type of pattern recognition receptor

Recognize structurally conserved molecules broadly shared by pathogens but distinguish from host molecules

Question 3

What is role of IgA in protection of GI tract?

Answer 3

IgA is produced by GALT

It coats the microrganism so it does not bind to epithelium. Does not destroy it

Question 4

GALT

Answer 4

Bulk of body’s immune defenses centered in GALT

Includes appendix, peyer’s patch and messentric lymph nodes

Question 5

Peyer Patch

Answer 5

Dome shaped lymphoid structure with B and T cell dependent areas
Facilitates entrance of lymphocytes into lymphoid organs from bloodstream