Neurodevelopment Flashcards
(22 cards)
Determined Cell
Cells that fate developed into a specialized cell despite changes in environment
Completely undetermined cells
Cells that RAPIDLY change due to alterations in environment
Committed Cells
Cells that have some attributes of a particular cell type but can change with environment
What type of cells divide asymmetrically?
Germ Cells
Inductive Signaling
Induction of select cells in a homogenous group leading to altered character (Short range or long range)
What does cells need for long range signaling?
Morphogens
____ controls development and ____ creates uniqueness.
Differential Gene Expression
Non-coding sequences
Blastula
Development stage after zygote
“Hollow filled ball of cells”
Ectoderm is the precursor for
nervous system and epidermis
Mesoderm is the precursor for
muscles and connective tissue
Endoderm is the precursor for
gut, lung and liver
Transformation of a blastula into a layered structure of a gut is called
gastrulation
The two types of inductive signaling include: (2)
Short Range and Long Range
Long Range Inductive Signaling
Substances that can diffuse through extracellular medium
Delta Notch signal determines the differentiation of what two types of cells?
Active Delta—> Nerve Cell
Inactive Delta—> Glial Cell
What are three ways to ensure diversity in pattern?
Combination Control
Cell memory
Sequential Induction
Combination Control
Response of a cell to a given signal may differ based on the presence of other signals
Cell Memory
Effect of a given signal depends on previous experiences of the cell which may have altered it chromatin, regulatory protein, transcription and RNA
Sequential Induction
Different signals formed/secreted in a spatial and temporal manner
Notch signaling pathway has what family of ligand and receptor?
Ligand–>Delta
Receptor–> Notch
Hedgehog signaling pathway has what family of ligand and receptor?
Ligand–>Hedgehog
Receptor–>Patched, Smoothened
WNT signaling pathway has what family of ligand and receptor?
Ligand–>WNT (Wingless)
Receptor–>Frizzled
