GI system embryology Flashcards Preview

Anatomy II > GI system embryology > Flashcards

Flashcards in GI system embryology Deck (26):
1

Which arteries supply the different parts of the gut?

unpaired branches of abdominal aorta

  • truncus coeliacus → foregut
  • a. mesenterica sup. → midgut
  • a. mesenterica inf. → hindgut

2

What are the derivatives of the foregut?

pharynx → ampulla pancreatica

  • pharynx
  • lower resp. system 
  • esophagus + stomach
  • duodenum proximal to opening of bile duct
  • liver + biliary apparatus + pancreas

3

How does the esophagus develop?

Where do its structures originate from?

  1. seperation from trachea by treacheoesophageal septum (cf. flashcards for resp. system)
  2. obliteration of lumen + recanalization

orgin:

  • endoderm → epithelium + glands
  • 4th + 6th pharyngeal arch → striated m.
  • splanchnic mesenchyme → smooth m.

4

How does the stomach develop?

 

slight dilation in caudal part of foregut in median plane

  1. dorsal border grows faster than ventral 
    → curvatura gastrica major
  2. rotation 90° clockwise around longitudinal axis

5

Explain the innervation of the stomach w/r/t its rotation

since:

  • left side → ventral surface
    → ant. wall innervated by truncus vagalis sin.
  • right side → dorsal surface
    → post. wall → innervated by truncus vagalis dex.

A image thumb
6

How do you call the structure attaching to the stomach? 

Where else does it attach?

What does it eventually form?

dorsal mesogastrium

  • attaches to: post. abdominal wall
  • contains: spleen, celiac artery
  • forms: omental bursa

ventral mesogastrium 

  • attaches to: ant. abdominal wall
    • duodenum to liver

7

How is the omental bursa formed?

Which structures does it form?

clefts forming in dorsal mesogastrium coalesce and form foramen omentale, demarcates opening to omental bursa (sac formed during rotation of stomach)

forms:

  • superior recess persists dorsal to right lung
  • inferior recess → disappears as layers of omentum majus fuse

8

How does the duodenum develop?

section around junction btw foregut and midgut 

  1. forms C-shaped loop (= ansa duodenalis)
  2. pushed into retroperitoneal position by developing stomach (not pars superior!) → ​sec. retroperitoneal
  3. lumen obliterates → recanalization

 

9

How do the liver and biliary apparatus develop?

outgrowth from distal part of foregut (= hepatic diverticulum) extends into septum transversum

  1. enlarges and divides into 2 parts btw ventral mesogastrium 
    cranial part: liver primordium
    - caudal part: gall bladder primordium
    - stalk of caudal part: ductus cysticus
    - stalk connecting both parts: common bile duct
  2. future common bile duct moves to dorsal aspect of duodenum as duodenum grows

10

How does the "interior" of the liver develop?

endodermal cells → cords of hepatocytes + endothelial lining of intrahepatic part of biliary apparatus

→ hepatic cords anastomose around hepatic sinusoids

11

When does hematopoiesis in the liver begin?

 

6th week → bright reddish color to the liver

12

When does bile formation begin?

How do you call the dark green intestinal contents?

12th week

meconium

13

The ventral mesentery gives rise to which structures?

  • omentum minus (= lig. hepatogastricum, lig. hepatoduodenale, lig. hepatoesophageale)
  • lig. falciforme
  • lig. coronarium

14

How does the pancreas develop?

endodermal cells from caudal end of foregut form pancreatic buds btw the layers of the mesentery

  • ventral pancreatic bud (near entry of bile duct)
  • dorsal pancreatic bud (larger + more cranially)
  1. duodenal rotation carries ventral pancreatic bud dorsally → posterior to dorsal pancreatic bud
  2. pancreatic buds fuse (ventral pancreatic bud → proc. uncinatus)
  3. pancreatic ducts fuse
     

15

Which pancreatic bud is responsible for which pancreatic duct?

ventral pancreatic bud:

  • ductus pancreaticus

dorsal pancreatic bud:

  • proximal part → ductus pancreaticus acc.
  • distal part → ductus pancreaticus

 


 

16

How does the "interior" of the pancreas develop?

 

 

endoderm of pancreatic buds forms network of tubules 

  • cell clusters at end → pancreatic acini 
  • groups of cells btw acini → islets of Langerhans

17

What are the derivatives of the midgut?

ampulla pancreatica → 1st 2/3 of colon transversum

  • duodenum distal to opening of bile duct
  • small intestine
  • cecum + appendix
  • colon ascendens + 1st 2/3 of colon transversum

18

How does the first part of the intestines develop?

  1. midgut enlarges
  2. physiological umbilical hernia
  3. rotation of midgut loop
  4. retraction of intestinal loops
  5. fixation of intestines

​meanwhile: cecum and appendix develop

A image thumb
19

What is the umbilical hernia?

Why does it happen?

midgut loop (= ansa umbilicalis intestini) projects into umbilical vesicle through omphalomesenteric duct

due to: 

  • rapidly growing midgut
  • relatively massive liver + kidneys
  • degenerating mesonephros

 

20

What is the embryological origin of the Meckel's diverticulum?

remnant of omphalomesenteric duct (= vitelline duct)

21

Describe the rotation of the midgut loop.

  1. 90° counterclockwise rotation around axis of a. mesenterica sup.
    → cranial limb (small intestine) → to the left
    → caudal limb (large intestine) → to the right
  2. cranial limb forms intestinal loops

22

Describe the retraction of the intestinal loops.

  1. enlargement of abdominal cavity → small intestine returns 
  2. further 180° counterclockwise rotation 
    → cecum + colon asc. → to the right

→ 270° in total

23

Describe the fixation of intestines.

What are the final lines of attachment of omentum majus?

organs pushed into sec. retroperitoneal position 
since their mesenteries fuse with post. abd. wall as they are pressed against it

  • rotation of intestine
    → duodenum (exc. pars superior)
    → head of pancreas 
  • enlargement of intestine
    → colon asc.
    → colon desc. 

⇒ final lines of attachment of omentum majus:
flexura duodenojejunalis → valva ileocecalis

24

Explain how cecum and appendix develop.

cecal diverticulum appears on antimesenteric border of caudal midgut loop

  1. apex grows slower than rest → appendicular diverticulum
  2. appendix increases in length
  3. AFTER BIRTH: cecum grows unequally → appendix comes to lie on medial side 

25

What are the derivatives of the hindgut?

  • distal 1/3 of colon transversum
  • colon descendens, sigmoideum
  • rectum
  • sup. part of anal canal
  • epithelium of urinary bladder + most of urethra

26

Which changes does the cloaca undergo?

dorsally/ventrally cloaca divided by urorectal septum

  1. septum grows towards cloacal membrane → seperation of
    - rectum + sup. part of anal canal
    - urogenital sinus
  2. lumen occluded +  recanalization → anal pit