Flashcards in Glycogen, Lysosomes, FA, Lipids Deck (67)
What is the role of LDL?
Delivers hepatic cholesterol to peripheral tissues;
Formed by hepatic lipase modification of IDL in the peripheral tissue;
Taken up by target cells via receptor-mediated endocytosis.
What is the role of HDL?
Mediates reverse cholesterol transport from periphery to liver.
Acts as a repository for apoC and apoE (which are needed for chylomicron and VLDL metabolism).
Secreted from both liver and intestine.
Which lipoprotein does alcohol increase the synthesis of?
A younger patient has some S/Sx of pancreatitis, hepatosplenomegaly, & eruptive/pruritic xanthomas. What is the risk for atherosclerosis? What is increased in the blood? What is the inheritance? What enzyme is deficient or altered?
type I => hyper-chylomicronemia => AR
Deficient in lipoprotein lipase or altered apolipoprotein C-2 causing
elevated Chylomicrons, TG, cholesterol in blood
No increased risk for atherosclerosis
A 20 yr old patient comes in after an MI w/ no drug use & exercises regularly. What will be found on physical exam? What is the inheritance? What is defective? What is elevated in the blood?
type 2a => familial hyper-cholesterolemia => AD
Absent (homozygous=cholesterol may be 700) or defective (heterozygous=cholesterol may be 300) LDL receptors
elevated LDL & cholesterol
Accelerated atherosclerosis; tendon (achilles) xanthomas;
A patient has had several bouts of pancreatitis along with many people in his family. What is elevated in blood? inheritance? What is the mechanism of pathology?
Type IV => hyper-tryglyceridemia => AD
Hepatic overproduction of VLDL causing
elevated blood levels of VLDL & TG