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Flashcards in Glycogen, Lysosomes, FA, Lipids Deck (67)
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What is the role of LDL?

Delivers hepatic cholesterol to peripheral tissues;
Formed by hepatic lipase modification of IDL in the peripheral tissue;
Taken up by target cells via receptor-mediated endocytosis.


What is the role of HDL?

Mediates reverse cholesterol transport from periphery to liver.
Acts as a repository for apoC and apoE (which are needed for chylomicron and VLDL metabolism).
Secreted from both liver and intestine.


Which lipoprotein does alcohol increase the synthesis of?



A younger patient has some S/Sx of pancreatitis, hepatosplenomegaly, & eruptive/pruritic xanthomas. What is the risk for atherosclerosis? What is increased in the blood? What is the inheritance? What enzyme is deficient or altered?

type I => hyper-chylomicronemia => AR

Deficient in lipoprotein lipase or altered apolipoprotein C-2 causing
elevated Chylomicrons, TG, cholesterol in blood

No increased risk for atherosclerosis


A 20 yr old patient comes in after an MI w/ no drug use & exercises regularly. What will be found on physical exam? What is the inheritance? What is defective? What is elevated in the blood?

type 2a => familial hyper-cholesterolemia => AD

Absent (homozygous=cholesterol may be 700) or defective (heterozygous=cholesterol may be 300) LDL receptors
elevated LDL & cholesterol

Accelerated atherosclerosis; tendon (achilles) xanthomas;
corneal arcus


A patient has had several bouts of pancreatitis along with many people in his family. What is elevated in blood? inheritance? What is the mechanism of pathology?

Type IV => hyper-tryglyceridemia => AD

Hepatic overproduction of VLDL causing
elevated blood levels of VLDL & TG


Differentiate familial dyslipidemias based on what is elevated in blood

type I-hyper-chylomicronemia => CM, TG, cholesterol

Type 2a - familial hypercholesterolemia => LDL, cholesterol

type IV - hyper-triglyceridemia => VLDL, TG