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Flashcards in Glycolysis Deck (70)
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1

Glucose to Glucose 6 Phosphate by ____

hexokinase

2

hexokinase ___ glucose ---> G6P

phopshorylates

3

hexokinase is not present in the ___

liver, there is glucokinase

4

what happens wtih G6P?

there is no transporter for G6P so it is stuck at the cell

5

γ-Phosphoryl of ATP is transferred to the ___ of Glu by Hexokinase

C6 hydroxyl 

6

when does the liver export glucose?

when glucose is low

 

this is why the liver has a less aggressive heokinase (glucokinase)

7

difference between affinity of glucokinase compared to heoxkinase? 

Liver Glucokinase has an affinity for Glu that’s 500-fold weaker than that of Hexokinase

8

G6P enters glycolysis?

when the cell needs energy

9

G6P is converted to F6P by

phopshoglucose isomerase

10

action of phopshoglucose isomerase on G6P 

PGI isomerizes an aldose to a ketose

11

after phopshorylation at the C1 hydroxyl group what is produced? why?

two equal 3 carbon fragments

 

due to PGI setting the stage for an aldol cleavage between C3/C4 (requires a carbonyl at C2)

12

phopshofructokinase transfers a γ-phosphoryl of ATP to the ___ of F6P to make it F1,6 BP

 C1 hydroxy

13

fructose 6-phopshate is converted into F 1,6 BP by

phosphofructokinase

14

___ plays a central role in the regulation of Glycolysis

phopshofructokinase

15

what cleaves fructose 1,6, biphosphate 

aldose

16

products?

17

what is dihydroxyacetone converted to?

GAP, the other product of the cleavage of f 16 BP

18

differene between DHAP and GAP?

DHAP is a KETOSE

GAP is an ALDOSE

19

what converts DHAP to GAP?

tripose-P-isomerase

20

GAP and DHAP are both

trioses

21

GAP gets ____ to be converted to 1,3-BPG by GAP dehydrogenase?

oxidized and phosphorylated

22

____ converts GAP to 1,3 BPG

GAP dehydrogenase

23

first step in glycolysis where you MAKE atp?

24

1,3 PBG is converted to 3PG by 

phosphoglycerate kinase

25

how many ATPs does this rxn produce?

2

26

this is an example of ___

substrate level phopshorylation

27

Phosphoglycerate Mutase moves the phosphoryl of 3PG to the ____ to get ____. 

C2 hydroxyl to give 2PG

28

___converts 3PG to 2PG

Phosphoglycerate Mutase

29

2PG is converted to PEP by

enolase

30

mechanism of conversion of 2PG by enolase to PEP

2PG is dehydrated