Glucose to Glucose 6 Phosphate by ____
hexokinase ___ glucose ---> G6P
hexokinase is not present in the ___
liver, there is glucokinase
what happens wtih G6P?
there is no transporter for G6P so it is stuck at the cell
γ-Phosphoryl of ATP is transferred to the ___ of Glu by Hexokinase
when does the liver export glucose?
when glucose is low
this is why the liver has a less aggressive heokinase (glucokinase)
difference between affinity of glucokinase compared to heoxkinase?
Liver Glucokinase has an affinity for Glu that’s 500-fold weaker than that of Hexokinase
G6P enters glycolysis?
when the cell needs energy
G6P is converted to F6P by
action of phopshoglucose isomerase on G6P
PGI isomerizes an aldose to a ketose
after phopshorylation at the C1 hydroxyl group what is produced? why?
two equal 3 carbon fragments
due to PGI setting the stage for an aldol cleavage between C3/C4 (requires a carbonyl at C2)
phopshofructokinase transfers a γ-phosphoryl of ATP to the ___ of F6P to make it F1,6 BP
fructose 6-phopshate is converted into F 1,6 BP by
___ plays a central role in the regulation of Glycolysis
what cleaves fructose 1,6, biphosphate
what is dihydroxyacetone converted to?
GAP, the other product of the cleavage of f 16 BP
differene between DHAP and GAP?
DHAP is a KETOSE
GAP is an ALDOSE
what converts DHAP to GAP?
GAP and DHAP are both
GAP gets ____ to be converted to 1,3-BPG by GAP dehydrogenase?
oxidized and phosphorylated
____ converts GAP to 1,3 BPG
first step in glycolysis where you MAKE atp?
1,3 PBG is converted to 3PG by
how many ATPs does this rxn produce?
this is an example of ___
substrate level phopshorylation
Phosphoglycerate Mutase moves the phosphoryl of 3PG to the ____ to get ____.
C2 hydroxyl to give 2PG
___converts 3PG to 2PG
2PG is converted to PEP by
mechanism of conversion of 2PG by enolase to PEP
2PG is dehydrated