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Flashcards in Oxidative Phosphorylation Deck (81)
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1

2,4-dinitrophenol is what class that prevents oxidative phosphorla?

uncoupler

2

mechanism fo action of 2,4-dinitrophenol

Discharges the pH gradient

3

2,4-dinitrophenol sx? use?

Marked increase in metabolism profuse sweating, collapse, death.

Formerly used for weight reduction

4

what class is Gramicidin? 

Ionophores

5

what sit he mechanism of action of Gramicidin

Forms a membrane pore permeable to protons

6

what are the sx of Gramicidin

Antimicrobial at low concentration. High concentration is fatal

7

what class is valinomycin?

Ionophores

8

Valinomycin mechanism of action

A membrane soluble, diffusional carrier of K+

9

valinomycin sx?

fatal

10

Oligomycin is a ___

 Phosphoryl- ation
Inhibitors

11

Oligomycin MOA? 

Prevents use of the electrochem. grad. to drive ATP synthesis

12

sx of Oligomycin

Fatal

13

what are the  Inhibitors of Electron

Transport?  (5)

1. Rotenone

2. Amytal (barbiturates)

3. Antimycin A

4. CN-

5. CO

14

Rotenone MOA

inhibits chain at 1st coupling site

15

Rotenone sx? uses?

sx -- Nausea, vomiting, convulsions, death from respiratory paralysis.

use -- Used in a topical ointment for treatment of chiggers. Also used as a poison for harvesting fish and as an insecticide

16

what meds Inhibits chain at 1st coupling site? 

Amytal (barbiturates)

rotenone

17

Amytal (barbiturates) sx? 

Nausea, vomiting, convulsions, death from respiratory paralysis. 

(same as rotenone)

18

Antimycin A MOA

Inhibits chain at 2nd coupling site

19

Antimycin A sx? uses? 

Fatal, used as fungicide and insecticide

20

CN- mOA

Inhibits chain at cytochrome a3, blocks
O2 binding by binding to FeIII

21

CN- sx? 

Convulsions, unconsciousness, death from respiratory paralysis. 

22

cyanide antidote 

Antidote: nitrite and thiosulfate intravenously (oxidizes some hemoglobin to met
hemoglobin which binds CN-). Administer O2

23

what  Inhibits chain at cytochrome a3, blocks O2 binding by binding to FeII??

CN and CO

24

what does death from co result from?

interaction with hemoglobin before it can reach the respiratory chain. 

25

sx of CO poisoning

Dizziness, vomiting, increase then decrease of pulse and respiration, collapse, death.

26

what to tx CO poisoning with

O2

27

 Inhibitors of mitochon-
drial trans- port systems
 include (2) 

Atractyloside Bongkrekic Acid

Mercurous salts

28

Mercurous salts sx 

Muscle spasms, depression, death from kidney failure usually within a week of exposure.

29

Mercurous salts MOA 

Inhibits Pi transport by
reaction with essential - SH

30

what were Mercurous salts formely used for? 

treating syphilis