Haematopoesis

Question 1

platelets have/dont have a nucleus

Answer 1

dont have

Question 2

name the granulocytes

Answer 2

neutrophils
eosinophils
basophils

Question 3

what do eosinophils do?

Answer 3

destroy parasites

modulate hypersensitivity reactions

Question 4

what do basophils do?

Answer 4

modulate hypersensitivity reactions

Question 5

how do monocytes differ morphologically from granulocytes?

Answer 5

nucleus is not segmented

not granular

Question 6

when does a monocyte become a macrophage?

Answer 6

when it goes into a tissue

Question 7

lifespan of neutrophils?

Answer 7

7-8hrs

Question 8

which would be the first cell to drop in numbers if the bone marrow is non-functioning?

Answer 8

neutrophils

Question 9

would platelets or RBCs drop in numbers first if the bone marrow is non-functioning?

Answer 9

platelets

Question 10

earliest form of a neutrophil?

Answer 10

myeloblast

Question 11

how does the nucleus of a neutrophil change as it develops?

Answer 11

it becomes more segmented as it matures

Question 12

platelet precursor cell?

Answer 12

megakaryocyte

Question 13

which cells in the bone marrow are polypoid and why?

Answer 13

megakaryocytes

cytoplasm doesnt divide but still forms platelets

Question 14

describe the daughter cells of a haematopoetic stem cell; how many does it make?

Answer 14

2
1 daughter cell identical to it
1 daughter cell different to it

Question 15

what cell has the ability to self renew?

Answer 15

haematopoetic stem cell

Question 16

bone marrow starts developing at week _

Answer 16

16

Question 17

first site of erythroid activity in development?

Answer 17

yolk sac

Question 18

haematopoeietic stem cells originate in the __derm

Answer 18

meso

Question 19

describe the arterial supply of the bone marrow

Answer 19

nutrient artery and periosteal network -> arterioles -> sinusoids

Question 20

how do sinusoids differ from capillaries?

Answer 20

larger

discontinuous basement membrane

Question 21

what are fenestrations?

Answer 21

gaps in bone marrow sinusoids that allow mature RBCs to leave

Question 22

what happens to sinusoids when red cells are released

Answer 22

inc blood flow

sinusoids dilate

Question 23

describe the relationship between megakaryocytes and sinusoids

Answer 23

MKCs extend long branching processes called proplatelets into the sinusoidal blood vessels

Question 24

what is yellow marrow? when is at its most populous?

Answer 24

fat

when youre older

Question 25

myeloid:erythroid ratio is usually...

Answer 25

1.5-3 : 1

Question 26

neutrophil precursor maturation is regulated by...

Answer 26

granulocyte-colony stimulating factor

Question 27

what hormone regulates growth and development of megakaryocytes?

Answer 27

thrombopoetin (as it eventually makes platelets)

Question 28

"horseshoe nucleus"

Answer 28

monocyte

Question 29

lymphoid cells require what extra test for assessment that non-lymphoid cells dont?

Answer 29

immunophenotyping

Question 30

neutrophils primarily reside in the blood/tissues

Answer 30

tissues

Question 31

what cells can marginate on the endothelial surface of BVs?

Answer 31

neutrophils

Question 32

myelocytes are precursor cells of what cells?

Answer 32

neutrophils

Question 33

earliest precursor cell of a macrophage after a myeloblast?

Answer 33

promonocyte

Question 34

why do you get an neutrophilia in steroid use?

Answer 34

break down marginating neutrophils so they have to circulate

Question 35

mast cell tryptase is released from..

Answer 35

mast cells

Question 36

mast cell tryptase is a marker of ..

Answer 36

degranulation | inc mast cells

Question 37

cytoplasm is minimal/plentiful in monocytes

Answer 37

plentiful

Question 38

monocytes circulate for __ days before entering the tissues

Answer 38

1-2

Question 39

abundant blue cytoplasm wrapping against neighbouring red blood cells....

Answer 39

glandular fever

Question 40

non-EBV causes of glandular fever

Answer 40

HIV CMV viral hepatitis toxoplasma

Question 41

IgM antibodies confirm recent/past infection

Answer 41

recent

Question 42

IgG antibodies confirm recent/past infection

Answer 42

past