Head and Neck Cancers Flashcards Preview

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Flashcards in Head and Neck Cancers Deck (33):
1

What are the four major divisions of cancer of the head and neck?

-Oral
-Pharyngeal
-Laryngeal
-Nasopharyngeal

2

True or false: black and white women have similar rates of oral cavity / pharyngeal cancers

True

3

Black men have (__)% highers rates of oral/pharyngeal cancers than white males

30%

4

Which ethnicity has the lowest rates of oral cavity/pharyngeal cancers?

Hispanics

5

Which ethnicity has the lowest rates of laryngeal cancers?

Asians

6

Both black men and women have 2x the risk of which cancer relative to white men and women?

Laryngeal

7

What is the most common type of head/neck cancer?

SCC

8

What are the chemicals that predispose patients to head and neck cancerS?

-Asbestos
-Ni
-Cr
-Ar
-Formaldehyde

9

What is the classic triad of plummer vinson syndrome?

-Anemia
-Esophageal webs
-Glossitis

10

What is the viral family of EBV? Genetic material? Enveloped?

-HSV (HHV-4)
-dsDNA
-Enveloped

11

What is the viral family of HPV? Genetic material? Enveloped?

-Papillomavirus
-dsDNA
-Naked

12

What are the two proteins that are utilized by HPV?

E6--inhibits p53
E7--inhibits Rb

13

Most people who have head or neck cancers have what environmental exposures?

EtOH and smoking

14

What are the major occupations that predispose patients to head and neck cancers? (5)

-Woodworking
-Leather manufacturing
-Ni refining
-Textile industry
-Ra dial painting

15

What are the strains of HPV that cause cancer?

16, 18, 31, 33

16

What are the HPV strains that cause genital warts?

6 and 11

17

What ear findings may be suggestive of head/neck cancer?

-Referred otalgia
-Serous OM

18

What are the throat findings suggestive of head/neck cancer? (3)

-Hoarseness
-Persistent odynophagia
-Dysphagia

19

What are the hematological findings suggestive of head/neck cancers? (2)

-Erythroplasia
-Non-healing ulcers

20

What are the nasal findings suggestive of head/neck cancer? (3)

-Recurrent epistaxis
-Nasal obstruction
-Submucosal mass

21

What is the process of progression with head/neck cancers?

Dysplasia
CIS
Carcinoma

22

White patches that do not rub off = ?

Leukoplakia

23

White patches on the tongue that rub off = ?

Candidiasis

24

What is the genetic mutation in Peutz-Jeghers syndrome?

STK11

25

What is the adenoma-carcinoma sequence of the GI tract?

APC
-Kras
-p53

26

What is the role of ASA in the prevention of GI carcinoma?

p53 mutations and increased expression of COX allow for progression to CA

27

What is the prognosis for red patches in the mouth that do not go away in 2 weeks?

20-30% will develop into cancer

28

How do you diagnose laryngeal cancer?

Endoscopy

29

What is the gross appearance of tumors in the mouth?

Nodular appearance

30

What type of voice will a patient with a unilateral vocal cord mass present with?

Breathy sounding

31

What type of voice will a patient with hypopharynx mass present with?

Garbled voice

32

The lymphatic in the true vocal cords are minimal. What is the significance of this, relative to hypopharyngeal cancers?

higher incidence of mets in hypopharyngeal than in true glottic cancers

33

What is the general treatment technique for head and neck cancers?

-Surgery with radiation and chemo