Hema Flashcards Preview

Pedia > Hema > Flashcards

Flashcards in Hema Deck (48):
1

Physiologic anemia of infancy usualy lasts for how many weeks?

8-12

2

Physiologic anemia of prematurity has hemoglobin levels of

7-9 g/dl

3

Does physiologic anemia of prematurity require treatment?

Yes EPO or transfusion

4

Most important sign of iron deficiency anemia

Pallor

5

Expected rise in hemoglobin per day after iron treatment

0.1-0.4 g/dl

6

Treatment for IDA

Elemental iron
3-6mg/kg/day

7

After treatment of IDA, Repeat CBC should be done after

4 weeks

8

Target cells
Heinz bodies
Decreased retic count
Normal RDW

Thalassemia

9

Definitive diagnosis of thalassemia can be done through

Hb electrophoresis

10

This infection should be watched out for in thalassemia because it eats up the free iron

Yersinia enterocolitica

11

Tachycardia and splenomegaly
Increased reticulocyte and MCHC normal platelet count

Spherocytosis

12

Defect in spectrin or ankyrin
Osmotic fragility test
Increased MCHC, retic count
Normal MCV

Spherocytosis

13

Vasoocclusive crisis
Autosomal recessive
Crew cut or hair on end appearance of skull in xray
Howell Jolly bodies

Sickle cell anemia

14

Treatment for sickle cell

Hydration and analgesia for acute crises

15

Most common hereditary bleeding disorder

vWD

16

Most common and most serious congenital coagulation factor deficiency?

Hemophilia A

17

Most common hereditary hypercoagulable disorder?

Factor V Leiden

18

Hallmark of hemophilia

Prolonged bleeding

19

Earliest joint hemorrhage in children

Ankles

20

Treatment for mild von willebrand disease type 1

Desmopressin

21

Laboratory finding in hemophilia

Increased PTT

22

Laboratory finding in vWD

Increased PTT and bleeding time

23

Laboratory finding in ITP

Increased bleeding time
Decreased platelet

24

Laboratory finding in vitamin K deficiency

Increased PT

25

Laboratory finding in DIC

Decreased platelet count
Increased PT PTT bleeding time

26

What type of leukemia in childhood will have the best response to chemotherapy?

ALL

27

Site of relapse of ALL

bone marrow
CNS
Testes

28

Site of spread of ALL

Liver
Spleen
Lymph nodes

29

<2 years >10 years old
Male
WBC >100,000 on presentation
CNS involvement
Mediastinal mass

Poor prognostic factors of what disease

ALL

30

Renal tumor of embryonal origin

Wilms tumor

31

Painless abdominal enlargement with flank mass that DOES NOT cross the midline

Wilms

32

Drug of choice for PCP prophylaxis in children with ALL undergoing chemotherapy is

Co-trimoxazole

33

Embryonic tumor of neural crest origin

Neuroblastoma

34

Most common site where neuroblasts migrate

Sympathetic ganglia and adrenals

35

Differential diagnosis of small, round, blue cell tumors

WARMER PN

Wilms
Acute leukemia
Rhabdomyosarcoma
Mesothelioma/medulloblastoma
Ewing sarcoma
Retinoblastoma
Primitive neuroectodermal tumor (PNET)
Neuroblastoma

36

Associated with:
Neurofibromatosis
Beckwith- Weidemann syndrome
WAGR syndrome

Wilms tumor

37

Associated with:
N-myc oncogene
Neurofibromatosis
Hirschprung
Tuberous sclerosis
Pheochromocytoma

Neuroblastoma

38

Horner syndrome
Abdominal mass that MAY cross the midline
Cord compression
Racoon eyes
Dancing eyes and feet

Neuroblastoma

39

Diagnosis for neuroblastoma

Urine VMA and HVA
Abdominal CT
Bone marrow aspirate

40

Long bones and skull
BM
Liver
LN
Skin

Most common metastatic sites of

Neuroblastoma

41

What are the B symptoms of
Lymphoma?

High grade fever
Weight loss
Night sweats

42

Regional lymphadenopathy
Chemotherapy
Bimodal age distribution
EBV, CMV, HHV 6
Reed Sternberg cells
Contiguous LN spread

Hodgkin lymphoma

43

Hodgkin lymphoma type that has the Best prognosis

Mixed cellularity lymphocyte predominant

44

Systemic adenopathy
Radiation for CNS involvement
Chemotherapy
60% of lymphomas in chidren and adolescent
EBV- Burkitt
Non contiguous LN spread

Non-Hodgkin

45

Results from failure or autoimmune destruction of myeloid stem cells

Aplastic anemia

46

Most likely cause of aplastic anemia

Idiopathic

47

Typical PBS finding in aplastic anemia

Hypocellularity and pancytopenia

48

Aplastic anemia with microcephaly, microphthalmia, hearing loss and limb anomalies

Fanconi anemia