Hematology #3 Flashcards Preview

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Flashcards in Hematology #3 Deck (21):
1

Transfusion reaction: Hemolytic Onset and treatment

Onset: Shortly after transfusion
Treatment: stop transfusion, supportive care

2

Transfusion reaction: Anaphylactic Pathology and S/S

Pathology: Hypersensitivity
S/S: Urticaria, dyspnea, wheezing

3

Transfusion reaction: anaphylaxis
Onset and treatment

Onset: within 30 minutes of transfusion
Treatment: stops transfusion, Epi, steroids

4

Transfusion reaction: Febrile
Pathology and S/S

Pathology: antibodies and leukocytes
S/S: fever, chills

5

Transfusion reaction: Febrile
onset and treatment

Onset: 30-90 minutes
Treatment: stop transfusion

6

Transfusion reaction: Circulatory overload
Pathology and S/S

Pathology: circulatory collapse
S/s: couch, cyanosis

7

Transfusion reaction: circulatory overload
Onset and treatment

Onset: anytime
Treatment: stop transfusion, Lasix

8

Transfusion reaction: Hemolytic pathology & s/s

Pathology: ABO incompatibility
S/S: Fever, chills, dyspnea and back pain

9

Patient blood type who is the most likely to develop a hemolytic reaction.

Type O blood
Can only receive type O

10

What percentage of hemolytic reactions will develop DIC?

30-50%

11

Hemolytic reaction treatments

Support hemodynamics with fluid and pressers
Maintain renal perfusion and function with fluid and diuretics
Prevention of DIC mainly with pressure support and oxygenation

12

Circulatory overload

Blood is colloidal, draws fluid into vascular spac

13

Indications for FFP

Coumadin therapy reversal, DIC, Antithrombin III deficiency (extended heparin tx), dilutional coagulopathy (>1 blood volume or 10 units PRBC's)

14

Ratio given with PRBCs

1:4 until 10 units PRBCs then 1:1

15

Dosing for coagulation driven by coags

Pt/PTT >1.5 - 1.8 normal

16

Coumadin OD considerations with FFP

Coumadin interfes with vit K (needed for clotting factors)
Vit replacement is part of tx
FFP Immediately replaces clotting factors

17

Platelets indication

Platelet deficiency
100k

18

One unit platelets will increase platelet count by what?

5-10k

19

What is cryoprecipitate?

A mixed blood product obtained by separating specific clotting factors from FFP

20

When is cryoprecipitate indicated?

DIC, hemophilia A, Von willebrand disease (vWD) or to stop TPA induced bleeding.

21

Cryoprecipitate dose

10ml / min
10 units