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Flashcards in Hematology Deck (51)
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31

What's the most common mutation that predisposes people to venous thrombus?

Factor V Leiden

32

What autosomal dominant bleeding disorder often presents with easy bruising, mucosal bleeding, skin bleeding and menorrhagia?

von Willebrand disease

33

What lab is used to monitor Heparin anticoagulation?

PTT

34

What is the main use for the direct thrombin inhibitors (dabigatran, argatroban, bivalirudin, desirudin)?

anticoagulation in patients that develop HIT

35

What lab is used to monitor warfarin anti-coagulation?

PT

36

Treatment for a heparin overdose?

Protamine sulfate

37

Smear shows peripheral blasts that are PAS + and TdT +. What is it?

ALL

38

Smear shows peripheral blasts that are PAS-, myeloperoxidase + and have Auer rods. What is it?

AML

39

Which cancer is associated with a t(9;22)?

CML (Philadelphia chromosome, bcr-abl, tyrosine kinase)

40

What is the treatment for CML?

Tyrosine kinase inhibitors (Imatinib, Dasatinib, Nilotinib--> all end in "-ib" like inhIBitor)

41

What do smudge cells on a smear indicate?

CLL

42

What does a smear with pseudo Pelget-Huet anomaly (neutrophils with 2 nuclear lobes connected by a thin strand) indicate?

Myelodysplastic syndromes

43

Symptoms of Multiple Myeloma?

CRAB
-hyperCalcemia
-Renal failure
-Anemia
-Back pain (bone lytic lesions)

44

What are the diagnostic tests for Multiple Myeloma?

-SPEP and UPEP (serum and urine protein electrophoresis)
-skeletal survey (look for bone lytic lesions)

45

What is the characteristic cell type seen on lymph biopsy in Hodgkin lymphoma?

-Reed-sternberg cell
-looks like owl eyes --> large binucleate cells with prominent nucleoli and clearing around the cell

46

What is the most common type of Hodgkin Lymphoma? What are the features of this?

-Nodular sclerosis.
-Nodules of lymphocytes separated by sclerotic bands of collagen, few reed-sternberg cells

47

What translocation is associated with Burkitt lymphoma?

t(8;14)

48

What does the histology of Burkitt lymphoma look like?

-Starry sky
-background of dense dark lymphocytes with scattered macrophages.

49

What are the common findings in polycythemia vera?

-thrombosis
-pruritis
-erythromelalgia (burning pain in the hands and feet with erythema, pallor or cyanosis)

50

What is associated with a translocation t(14;18)?

Follicular lymphoma (non-hodgkin)

51

Most common lymphoma in the US?

Diffuse large B cell lymphoma