Flashcards in Hematology Deck (51)
What's the most common mutation that predisposes people to venous thrombus?
Factor V Leiden
What autosomal dominant bleeding disorder often presents with easy bruising, mucosal bleeding, skin bleeding and menorrhagia?
von Willebrand disease
What lab is used to monitor Heparin anticoagulation?
What is the main use for the direct thrombin inhibitors (dabigatran, argatroban, bivalirudin, desirudin)?
anticoagulation in patients that develop HIT
What lab is used to monitor warfarin anti-coagulation?
Treatment for a heparin overdose?
Smear shows peripheral blasts that are PAS + and TdT +. What is it?
Smear shows peripheral blasts that are PAS-, myeloperoxidase + and have Auer rods. What is it?
Which cancer is associated with a t(9;22)?
CML (Philadelphia chromosome, bcr-abl, tyrosine kinase)
What is the treatment for CML?
Tyrosine kinase inhibitors (Imatinib, Dasatinib, Nilotinib--> all end in "-ib" like inhIBitor)
What do smudge cells on a smear indicate?
What does a smear with pseudo Pelget-Huet anomaly (neutrophils with 2 nuclear lobes connected by a thin strand) indicate?
Symptoms of Multiple Myeloma?
-Back pain (bone lytic lesions)
What are the diagnostic tests for Multiple Myeloma?
-SPEP and UPEP (serum and urine protein electrophoresis)
-skeletal survey (look for bone lytic lesions)
What is the characteristic cell type seen on lymph biopsy in Hodgkin lymphoma?
-looks like owl eyes --> large binucleate cells with prominent nucleoli and clearing around the cell
What is the most common type of Hodgkin Lymphoma? What are the features of this?
-Nodules of lymphocytes separated by sclerotic bands of collagen, few reed-sternberg cells
What translocation is associated with Burkitt lymphoma?
What does the histology of Burkitt lymphoma look like?
-background of dense dark lymphocytes with scattered macrophages.
What are the common findings in polycythemia vera?
-erythromelalgia (burning pain in the hands and feet with erythema, pallor or cyanosis)
What is associated with a translocation t(14;18)?
Follicular lymphoma (non-hodgkin)