Hematology/Oncology Disorders Flashcards Preview

USMLE Step Two > Hematology/Oncology Disorders > Flashcards

Flashcards in Hematology/Oncology Disorders Deck (95)
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61

translocation 9;22

CML philadelphia chromosome

62

most common form of hodgkin's lymphoma

nodular sclerosis

63

starry-sky pattern due to phagocytosis of apoptotic tumor cells

burkitt's lymphoma

64

high hematocrit/hemoglobin, pruritis, burnign pain in hands or feet

polycythemia vera

65

blood smear with hair-like projections, splenomegaly

hairy cell leukemia

66

antiretroviral that causes lactic acidosis

NRTIs

67

antiretroviral that causes GI intolerance

protease inhibitors

68

antiretroviral that causes pancreatitis

didanosine, stavudine, zalcitabine, ritonavir

69

antiretroviral that causes peripheral neuropathy

didanosine, stavudine, zalcitabine

70

antiretroviral that causes megaloblastic anemia

zidovudine

71

antiretroviral that causes rash

NNRTIs

72

antiretroviral that causes hyperglycemia, diabetes mellitus, and lipid abnormalities

protease inhibitors

73

antiretroviral that causes bone marrow suprression

zidovudine

74

antiretroviral that is given to pregnant women with HIV

HAART therapy +/- ziduvodine during labor

75

antiretroviral regimen for occupational HIV exposures

HAART: 2 NRTIS + NNRTI/protease inhibitor
zidovudine + lamivudine

76

antibiotic prophylaxis for HIV patients

< 200: TMP-SMX/dapsone for PCP
< 100: erythryomycin/clarithromycin for MAC

77

treatment for CLL

rituximab

78

no alpha-globin production, fetal death occurs

hydrops fetalis
4 abnormal alpha genes

79

minimal alpha-globin production, chronic hemolytic anemia, pallor, splenomegaly, microcytic RBCs on blood smear, decreased lifespan

hemoglobin H disease
3 abnormal alpha genes

80

reduced alpha-globin production, mild anemia, microcytic RBCs and target cells

alpha-thalassemia minor
2 abnormal alpha genes

81

generally asymptomatic hematologic disorder, children are at increased risk for alpha-thalassemia

alpha-thalassemia minima
1 abnormal alpha gene

82

no beta-globin production, asymptomatic until decline of fetal hemoglobin, growth retardation, increase in hemoglobin A2 and F, patients die in childhood without transfusions

beta-thalassemia major
2 abnormal beta genes

83

reduced beta-globin production, mild anemia, transfusions may be needed during periods of stress

beta-thalassemia minor
1 abnormal beta gene

84

treatment for anti-phospholipid syndrome

heparin, warfarin
hydroxychloroquine

85

prophylaxis when CD4 < 200

TMP-SMX for toxoplasmosis and PCP

86

treatment for porphyria cutanea tarda

phlebotomy and chloroquine

87

treatment for coxsackie virus herpangina

reassurance and symptomatic treatment

88

causes of distributive shock

sepsis, anaphylaxis, burns, adrenal insufficiency, drug reactions, and CNS injury

89

ovalo-macrocytes, leukopenia, thrombocytopenia, neutrophils with decreased segmentation

myelodysplastic syndrome

90

treatment for polycythemia vera

serial phlebotomy, antihistamines (for pruritis), aspirin (prevent strokes), hydroxyurea (bone marrow suppression)

interferon-alpha is a refractory treatment