HEME 3.81 Flashcards Preview

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Flashcards in HEME 3.81 Deck (10)
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1
Q

decreased vitamin B12 levels produce RBCs that are ____________

A

Macrocytic (elevated MCV)

2
Q

what is another term used to describe Vit. B12 deficient anemia

A

megaloblastic anemia

3
Q

The metabolic pathway involved in replication of DNA are complex, and involve both ______ __ and ______

A

Vit. B12, Folate

4
Q

why are cells in Vit. B12 deficient anemia macrocytic

A

RNA synthesis in not affected and so protein synthesis continues —-> the protein accumulates and the red cells get larger

5
Q

what is a decrease in Vit. B12 due to Intrinsic factor (IF) called

A

pernicious anemia

6
Q

Lack of IF is either on autoimmune attack on ___ or on the ______ ____ in the ______

A

IF, perietal cells, stomach

7
Q

what are the three main reasons for Vit. B12 deficiencies

A

Lack of IF, Dietary, Total or partial gastrectomy or other stomach procedures

8
Q

Does Folate require Intrinsic factor

A

No

9
Q

what are four potential causes of Folate deficient anemia

A
  • Poor nutrition
  • increased requirements
  • malabsorption
  • Drugs
10
Q

with anemia due to acute blood loss, the anemia is desctribed as

A

Normocytic