Herpesviridae Flashcards
(34 cards)
Herpesviridae
______ viruses of the herpes group cause a wide range of spectrum of *human diseases
* Nearly_____ viruses of the herpes group infect many different animal species
Eight
100
T or F
Some - extensive host-cell range
Others - narrow range of host cells
True
Herpesviridae
• Outstanding property - ability to establish_________ and _________
• Frequent reactivation in_____ and ____ patients
• Serious complications & clinically quite different from primary infection
lifelong persistent infections and undergo periodic reactivation
elderly & immunosuppressed
Greek_____ meaning “to creep or crawl” in reference to the spreading nature of herpetic lesions;
also from_____ referring to an animal that goes on all fours
herpein
herpeton
Properties of Herpesviruses
- size?
- enveloped or non-enveloped?
- strand?: genomes possess terminal & internal repeated sequences
- Indistinguishable by _______ microscopy
-______capsomeres
Large viruses
Enveloped
dsDNA
electron
162
Herpesviruses
Virion:
- shape???
- diameter??? (icosahedral)
Genome:
- Double-stranded DNA,
- linear,
- 125-240 kbp,
- reiterated sequences
Spherical
150-200 nm
Herpesviruses
Proteins:
More than____ proteins in virion
Envelope:
Contains viral_____, Fc receptors
More than 35
glycoproteins
Herpesviridae
Replication:
Nucleus, bud from nuclear membrane
Herpesviruses
Outstanding characteristics:
Encode many enzymes
Establish latent infections
Persist indefinitely in infected hosts
Frequently reactivated in immunosuppressed hosts
Some cause cancer
HERPESVIRUSES - latent infections
T or F
Infection remains in the body for life
True!
: Virus can remain dormant for periods to time, hiding within the cells of the body by evading the host’s immune system.
• Latent infections
• “______” - not replicating
quiescent
Stimuli that can reactivate the virus?
• Axonal injury, fever
• Immune suppression by cytotoxic drugs
• Physical & emotional stress
• Temperature changes
• Exposure ultraviolet light
• Menstruation
• Pregnancy
• Lactation
• Malnutrition
• Excessive fatigue
• Sexual contact
Latent Infections: NEURONS
1-Herpes simplex virus type 1
2-Herpes simplex virus type 2
3-Varicella-zoster virus
Latent Infections: GLANDS/ KIDNEYS
Cytomegalovirus
Latent Infections: LYMOHOID TISSUE
6-Human herpesvirus 6
7-Human herpesvirus 7
4-Epstein-Barr virus
8-Kaposi sarcoma-associated herpesvirus
Short, cytolytic
Herpes simplex virus type 1
Herpes simplex virus type 2
Varicella-zoster virus
Long, cytomegalic
CMV
Long, lymphoproliferative
Human herpesvirus 6
Human herpesvirus 7
Variable, lymphoproliferative
Epstein-Barr virus
Kaposi sarcoma-associated herpesvirus
Alpha - Fast Growing
Herpes simplex virus type 1
Herpes simplex virus type 2
Varicella-zoster virus
Beta - Slow growing
Cytomegalovirus
Human herpesvirus 6
Human herpesvirus 7
Gamma
Epstein-Barr virus
Kaposi sarcoma-associated herpesvirus
HHV-1 or HSV-1
HHV-2 or HSV-2
Genus:
Simplexvirus
