Hist for Path: 2 Flashcards Preview

MHD V: Renal > Hist for Path: 2 > Flashcards

Flashcards in Hist for Path: 2 Deck (22):
1

What do afferent arterioles arise from?

Interlobular arteries

2

What do efferent arterioles arise from?

Glomerular capillaries

3

What is mesangial matrix?

- Area in glomeruli between capillaries that holds them together

4

What is name of smooth muscle in glomeruli that regulates blood flow and filtration?

- Mesangium

5

3 functions of mesangium?

1. Contraction to regulate flow: smooth muscle cell
2. Structural support
3 Phagocytosis

6

Where are the fenestrations found?

- Cell walls of endothelial cells

7

What does basement membrane divide?

Endocapillary: mesangial
Extracapillary: Urinary space

8

What is in visceral epithelium?

Podocytes

9

What is in between foot processes of epithelium?

Slit diaphragm

10

What is the glomerular filtration barrier?

"Glomerular basement membrane" made of:
1. Basal lamina of endothelial
2. Podocytes

11

What does glomerular membrane prevent from filtering?

1. Large molecules: Proteins
2. Negative molecules: albumin

12

What is immunofluorescence used to detect?

1. Complement
2. Immunoglobulins

13

Components of the nephron?

1. Glomeruli
2. Prox tubule
3. Loop
4. Distal

14

Where does the distal tubule pass?

Near the glomerulus

15

Which tubules have wider lumen?

Distal

16

What structures are not found in medulla?

1. Glomeruli
2. Proximal tubule
3. Distal tubule

17

What is found in medulla?

1. Loop of henle
2. Collecting ducts

18

What is found on surface of proximal tubule?

- Brush border greatly increasing resorptive ability

19

What is the macula densa?

- Region of distal tubule that runs by glomerulus

20

What is the JG apparatus?

- Formed by distal tubule and afferent arteriole
- Regulates BP and filtration rate
- Regulates based upon distal [] of NaCl

21

What is loss of glomerular slit diaphragms and appearance of a continuous layer of podocyte cytoplasm indicative of?

MCD

22

What happens in MCD?

Loss of glomerular slit diaphragms and appearance of continuous layer of podocyte cytoplasm