Histology: Connective tissue (lecture) Flashcards Preview

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Flashcards in Histology: Connective tissue (lecture) Deck (63)
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1

What type of connnective tissue surrounds vessels and nerves?

loose CT (acts to fill and pack around)

2

T or F: dense CT has thinner fibers than loose CT?

False

3

What type of connective tissue is characterized by loose packing of its fibers?

Loose CT

4

What type of CT has large, closely packed fibers and contains cells that are mostly fibroblasts?

Dense CT

5

What are 4 areas where dense irregular CT can be found?

Stroma of organs
dermis of skin
periosteum and perichondrium
capsules of organs

6

What are 3 areas where dense regular CT can be found?

tendons
ligaments
aponeurosis

7

What does dense regular CT consist of?

fibroblasts in linear rows and paralel-oriented collagen fibers

8

What type of collagen is typically found in dense regular CT?

type I - resisted tensile stress

9

Where can reticular connective tissue be found? (5 places)

bone marrow
lymph nodes
lymph nodules
spleen
tonsils

10

T or F: reticular cells are modified fibroblasts?

True

11

What type of collagen makes up reticular fibers?

type III collagen

12

What allow special stains to be used in reticular fiber visualization?

Lots of carbohydrates

13

Compare reticular cells to fibroblasts

they are branching and have much more cytoplasm (they lie along the length of the reticular fiber)

14

What type of cells and fibers are most important in lymph nodes and blood forming organs?

Reticular cells

15

What is the earliest CT in the embryo?

mesenchyme - undifferntiated and can form all kinds of CT

16

T or F: mesenchyme contains sparse reticular fibers in an abundant ground substance?

True

17

T or F: Mesenchymal cells are non-existent in adulthood

False - they are more common in children but a smaller amount persist into adulthood

18

What is a pericyte?

adult mesenchymal cell that can give rise to fibrolasts and participate in new vessel formation during wound healing

19

How does CT participate in tissue repair in the body most often?

fibroblasts become myofibroblasts and mesenchymal stem cells

20

Describe what scar tissue is.

dense irregular CT that may compromise function (e.g. cornea)

21

What are myofibroblasts derived from?

fibroblasts

22

What cells are partly responsible for wound contraction?

myofibroblasts

23

T or F: myofibroblasts are intermediates between fibroblasts and smooth muscle because they contain actin.

True

24

How do myofibroblasts work?

They have proteins attached to collagen outside of cell and actin in the cell. The proteins move along actin and grip onto collagen to pull cells together

25

What happens as a clot forms in the skin?

macrophages and neutophils invade and clean up debris, dead cells, degrade ECM and collagen

26

What are growth factors in the wound produced by?

macrophages

27

What do growth factors in the wound stimulate?

fibroblasts and mesenchymal stem cells proliferate and re-synthesize ECM (sometimes scar = hyperprolferative)

28

T or F: collagen metabolism is low in adults

True - degration and deposition = usually equal

29

In what adult tissue is collagen metabolized at a higher rate?

scar tissue

30

What types of cells modulate collagen degradation?

Fibroblasts, macrophages, neutrophils = collagenases