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Flashcards in HRM Week 7 Deck (15):

Describe what a left shift means in terms of looking at at a blood film

Patient has immature forms of blood cells on the blood film


What are colony stimulating factors?

They are glycoproteins that bind to the surfaces of haematopoietic stem cells and activate intracellular signalling to cause proliferation and differentiation of the stem cells. Different CSF give rise to different lineages of blood cells. Such as GM-CSF, M-CSF


What are some things that cause neutropenia?

Chemotherapy, drugs, toxins, bone marrow failure, spleenomegaly, congenital, acquired, severe infection


What are some things that cause neutrophilia?

Infection, trauma, tissue destruction, corticosteroids, metabolic disorders


What are some things that cause decreased numbers of eosinophils?

Bacterial infection, acth administration


What are some things that cause eosinophilia?

Hypersensitivity reactions, parasitic infection, drug therapy, pulmonary disease, myeoloproliferative disease


What are some things that cause increased numbers of monocytes

MyoBacterial infections, myeoloproliferative disease, subacute bacterial endocarditis


What are some things that cause a decrease in numbers of monocytes

Hairy cell leukemia and corticosteroids


What are some things that cause decreased numbers of lymphocytes?

Congenital immunodeficiency, HIV/AIDS, drugs , GI diseases


What are some things that cause increased numbers of lymphocytes?

Viral infections, some fungal, parasitic infections, rare bacterial infections, drug sensitivity, immunologic disease


Describe neutropenia?

A reduction in Granulocyte numbers. Can be decreased production, increased destruction or congenital


Describe agranulocytosis?

Severe form of neutropenia. Means that there are no granulocytes in blood smear.


List some clinical features of neutropenia

Chills, fever, fatigue, ulcers


What is toxic granulation?

When neutrophils have too many granules. The are often very much darker than normal. It occurs when they are actively phagocytosing bacteria.


What do lymph node follicles look like in lymphadenitis?

Normal but more lymphocytes, clear differentiation between darker and lighter zone and a clear mantle zone. Also more tangible body macrophages eating up the dead lymphocytes.