Hyperlipidemia drugs

Question 1

HMG-CoA reductase inhibitors end with?

Answer 1

-Statin

Question 2

what does statins do?

Answer 2

stops the production of cholesterol in liver and increase LDL receptors

Question 3

statins should be taken around?

Answer 3

evening/night

Question 4

what is the exception statin med. that doesn’t need to be taken at night?

Answer 4

rosuvastatin (crestor)

Question 5

if pt has high LDL, you should take ?

Answer 5

statins (decreases up to 55% of LDL)
-triglycerides decrease: up to 30%

Question 6

side effects of statins?

Answer 6

rash, GI, myopathy (muscle weakness/pain), Rhabomyolysis,
elevated liver enzymes

Question 7

what is rhabdomyolysis

Answer 7

rapid muscle breakdown → myoglobin leaks into blood → can damage kidneys and heart if not treated quickly.

Question 8

statin medications lower?

Answer 8

C reactive protein (CRP)

Question 9

Niacin are?

Answer 9

vitamin (B3)

Question 9

you should not take statins with?

Answer 9

grape fruit juice! (decreases effectiveness)

Question 10

if triglycerides are your problem you shoud take?

Answer 10

Niacin (lowers up to 50%)
-HDL increases by 15-35%

Question 11

Niacin function?

Answer 11

inhibits the synthesis and secretion of VLDL and LDL

Question 12

CPR is a?

Answer 12

tests for inflammation to the heart (ESR)

Question 13

ESR (test for everywhere) is called?

Answer 13

sed rate

Question 14

side effects of niacin>

Answer 14

flushing of face, pruritus, hypotension ortho

Question 15

treatment of flushing?

Answer 15

aspirin

Question 16

Fibric acid derivatives function?

Answer 16

decrease hepatic synthesis and scretion of VDL. targets lowering triglycerides

Question 17

what medication to give is someone has high triglycerides?

Answer 17

fibric acid derivatives (decreases trigyl. levels up to 50%)

Question 18

when taking fibric acid derivatives and statins, pt may see increase A.E of?

Answer 18

myopathy

Question 18

side effects of fibric acid derivatives

Answer 18

rashes, N/d, elevated liver enzymes

Question 18

fibric acid derivatives increases effects of ?

Answer 18

warfairn

Question 19

myopathy can lead to?

Answer 19

rhabomyolysis

Question 20

myoglobin, CPK (creatine phosphokinase) get stuck at?

Answer 20

kidneys (may get damaged), tea colored pee, bp drops

Question 21

rhabomyolysis realeases?

Answer 21

myoglobin, CPK (creatine phosphokinase)

Question 22

omega-3 fatty acid function?

Answer 22

inhibits synthesis and/or secretion of triglycerides

Question 23

when do we use omega-3 fatty acid?

Answer 23

for pt with serve hypertriglceriemia (higher than 500)

Question 24

what is a monoclonal antibody?

Answer 24

proprotein converatse subtilisin/kixin 9 (PCSK9)

Question 25

examples of PCSK9?

Answer 25

evolocumab and alirocumab (ONLY IV)

Question 26

(PCSK9) function?

Answer 26

lower LDL (for ppl who have hypercholesterolemia)

Question 27

Zetia medication function?

Answer 27

inhibits the intestinal absorption of cholesterol (decreases LDL, trigly. and increases HDL)

Question 28

what is a side effect of zetia

Answer 28

greasy bowel movement

Question 29

Fibric acid derivatives medication example?

Answer 29

gemfibrozil (Lopid)

Question 30

another example of Niacin medication

Answer 30

nicotonic acid

Question 31

example of omega-3 medication

Answer 31

Icosapent ethyl (vascepa)

Question 32

what type of effect does digoxin have?

Answer 32

positive inotropic and negative chronotropic, negative dromotrope

Question 33

verapamil has what type of effect?

Answer 33

negative dromotrope and decreases everything else: BP, iso, chron