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Flashcards in Hypertension Deck (72)
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61

What do you use with reserpine and guanethdine to avoid fluid retention?

a diuretic pref a thiazide

62

What are the potential adverse effects of diuretics?

electrolyte disturbance
hyperglycemia
hypotension
lipid abnormalities
photosensitvity
ototoxicity
hyperuricemia

63

What are two aldosterone antagonists?

spironolactone
eplerenone

64

What are the mechanism of ACE inhibtitors?

block bradykinin degradation which stimulate syntehsis of other vasodilating substances like PGE2 and prostacyclin

blocks conversion of angiotensin I to angiotensin II

65

What disease can ACE inhibitiors it prevent or regress?

left ventricular hypertrophy

66

What are the adverse effects associated with ACE inhibitors?

cough
angioedema
hyperkalemia
neutropenia, agranulocytosis, proteinuria, glomerulonephritis, acute renal failure

67

What is the angiotensin II receptor blocker?

ARB, don't block bradykinin breakdown
less cough than ACE inhibitor

68

What is the renin inhibitor?

aliskiren; angiotensinogen to angiotensin I inhibitor

69

What are the precautions needed to be taken with ACE inhibitor or arbs?

can cause kidney failure
in pts with severe bilateral renal artery steoniss
pregnancy

70

What drug should you use in hypertensive emergency?

sodium nitroprusside
or
-nicardipine
-clevidipine
-fenoldopam
-nitro
-hydralazine
-labetalol
-esmolol

71

Combination therapy usually involves what?

two or more agents to control HTN
one should be a thiazide unelss contraindicated

72

What is resistant HTN?

fialure to achieve BP goal on 3 drug regimen