I - Cell Injury, Cell Death and Adaptations Flashcards Preview

Patho > I - Cell Injury, Cell Death and Adaptations > Flashcards

Flashcards in I - Cell Injury, Cell Death and Adaptations Deck (102)
Loading flashcards...
1

Increase in SIZE of cells resulting in increased size of organ.

Hypertrophy(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 34

2

Increase in NUMBER of cells

Hyperplasia(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.35

3

Hypertrophy of hyperplasia?Uterus during pregnancy

Both. Estrogen stimulates SM hyperthrophy and hyperplasia (TOPNOTCH)Robbins Basic Pathology, 9th ed. p.34

4

Hypertrophy or hyperplasia?Wound healing

Hyperplasia(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.4

5

Hypertrophy or hyperplasia?
Female breast at puberty

Both. (TOPNOTCH) Robbins Basic Pathology 9th ed., p 36

6

Cellular adaptation of non-dividing cells (i.e., myocardial fibers)

Hypertrophy (TOPNOTCH)

7

50 y/o male with untreated hypertension for several years. What cellular adaptation will be most likely seen in the myocardium?

Hypertrophy (TOPNOTCH)

8

40 y/o male underwent partial hepatectomy. What cellular adaptation will the liver most likely undergo?

Hyperplasia(TOPNOTCH)

9

The most common stimulus for hypertrophy of muscle

Increased workload (TOPNOTCH) Robbins Basic Pathology, 9th ed., p.34

10

Hypertrophy or hyperplasia? Benign prostate enlargement that can cause lower urinary tract symptoms (weak stream, straining, hesitancy) *SEE SLIDE 1.1

Hyperplasia(Case of BPH) (TOPNOTCH)

11

Stimulus for hyperplasia in BPH

Hormonal stimulation by androgens. (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 36

12

Cellular adaptation in papilloma virus infection

Hyperplasia (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 36

13

Reduction in the size of an organ or tissue due to decrease in cell size and number

Atrophy(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 35

14

60 y/o female has been experiencing hot flushes and irritability. Her uterine epithelium will most likely reveal what type of cellular adaptation?

Atrophy(in menopause)(TOPNOTCH)

15

Chronic production of this cytokine is thought to be responsible for appetite suppression and lipid depletion, culminating in muscle atrophy and marked muscle wasting (cachexia)

Tumor necrosis factor (TNF)(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 35

16

A reversible change in which one differentiated cell type is replaced by another cell type.

Metaplasia (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 37

17

A 49 y/o female had a chronic history of heartburn. Biopsy done showed glandular changes in the distal epithelium of the esophagus. What cellular adaptation is present? *SEE SLIDE 1.2

Metaplasia. This is a case of Barret's esophagus (squamous to glandular epithelium) (TOPNOTCH)

18

Most common epithelial metaplasia

Columnar to squamous(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 37

19

Type of metaplasia in trachea and bronchi in habitual cigarette smoking

Columnar to squamous(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 37

20

This is the first manifestation of almost all forms of injury to cells.

Cellular swelling(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.8 *SEE SLIDE 1.3

21

Type of cell death characterized by nuclear dissolution, WITHOUT complete loss of membrane integrity.

Apoptosis(TOPNOTCHRobbins Basic Pathology, 8th ed. p.7

22

Type of cell death which is energy-dependent, tightly regulated, and associated with normal cellular functions. Often physiologic. Undergoes shrinkage and fragmentation.

Apoptosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.7

23

Type of cell death which results from a pathologic cell injury. Undergoes cellular swelling and eventual pyknosis, karyorrhexis, and karyolysis.

Necrosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.9

24

Type of cell death associated with inflammation.

Necrosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.10

25

It is the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis. There is nuclear shrinkage with increased basophilia.

Pyknosis(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.42

26

It is the destructive fragmentation of the nucleus of a dying cell.

Karyorrhexis (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.10

27

It is the complete dissolution of the chromatin of a dying cell.

Karyolysis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.10

28

Small clear vacuoles within the cytoplasm, representing pinched-off segments of the endoplasmic reticulum.

Cellular swelling, hydropic change or vacuolar degeneration (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.23 *SEE SLIDE 1.3

29

Appearance of lipid vacuoles in the cytoplasm. Often seen in cells participating in fat metabolism (liver, heart)

Fatty Change(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.23 *SEE SLIDE 1.4

30

REVERSIBLE or IRREVERSIBLE INJURY: Surface blebs, increased eosinophilia of the cytoplasm, cellular swelling.

Reversible/ Early Ischemic Injury(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.18

Decks in Patho Class (48):