II - Acute and Chronic Inflammation Flashcards Preview

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Flashcards in II - Acute and Chronic Inflammation Deck (96)
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1

Initial vascular response to injury

Vasoconstriction.(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.33

2

Inflammation characterized by exudation of fluid and plasma protein and a predominantly neutrophilic leukocyte accumulation.

Acute inflammation(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 71

3

Inflammation typified by influx of lymphocytes and macrophages associated with vascular proliferation and deposition of connective tissue.

Chronic inflammation(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 71

4

Five cardinal signs of inflammation

Heat (calor)redness (rubor)swelling (tumor)pain (dolor)loss of function (functio laesa)(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 71

5

An ultrafiltrate of blood which contains little protein, little or no cellular material and low specific gravity as a result of osmotic or hydrostatic imbalance across the vessel wall WITHOUT increase in vascular permeability.

Transudate. (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 73

6

An extravascular fluid with high protein content. Its presence implies an increased vascular permeability, triggered by tissue injury and ongoing inflammatory reaction.

Exudate(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 73

7

Effect of histamine on vascular smooth muscle

Vasodilation. (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 73

8

The most common mechanism of increased vascular permeability.

Contraction of endothelial cells resulting in increased interendothelial spaces. (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 74

9

Proliferation of lymphatic vessels and painful enlarged lymph nodes secondary to inflammation.

Reactive or inflammatory lymphadenitis. (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 74

10

Molecules in the endothelium and leukocyte responsible for this stage of vascular inflammatory response: Rolling

P and E-Selectins on endothelium with Sialyl-Lewis-X on leukocyte; Glycam-1, CD-34 on endothelium with L-selectin on leukocyte (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 36 *SEE SLIDE 2.1

11

Molecules in the lymphocyte responsible for this stage of vascular inflammatory response: Firm adhesion

ICAM-1 on endothelium with CD11/CD18 integrins (aka, LFA-1, Mac-1) on leukocyte; VCAM-1 on endothelium with VLA-4 on leukocyte (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 36 *SEE SLIDE 2.1

12

Molecules in the endothelium responsible for this stage of vascular inflammatory response:
Transmigration

PECAM-1/CD 31(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 77 *SEE SLIDE 2.1

13

CELLS AND MOLECULES INVOLVED IN: Chronic transplant rejection

Lymphocytes, MACROPHAGES and CYTOKINES (TOPNOTCH) Robbins Basic Pathology, 9th ed. P 41

14

CELLS AND MOLECULES INVOLVED IN: Acute transplant rejection

Lymphocytes, ANTIBODIES and COMPLEMENT (TOPNOTCH) Robbins Basic Pathology, 9th ed. P 41

15

The process of leukocyte accumulation at the periphery of blood vessels

Margination(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 75

16

Arrange the following steps in the inflammatory response:
A. Recruitment of leukocytes
B. Regulation of response
C. Recognition of injurious agent
D. Removal of agent
E. Resolution

C, A, D, B, E (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 72

17

Arrange the steps in leukocyte recruitment:A. TransmigrationB. Rolling C. MarginationD. Firm adhesion

C, B, D, A (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 75

18

Process of coating microorganisms with proteins that facilitate phagocytosis.

Opsonization (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 75

19

A lymphocyte with ingested microorganism fused with lysosome is called _______.

Phagolysosome(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 78

20

The process of migration of the leukocytes through the endothelium.

Transmigration or diapedesis. (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 76

21

Process of leukocyte migration toward sites of infection or injury along a chemical gradient.

Chemotaxis (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 77

22

The most important lysosomal enzyme involved in bacterial killing.

Elastase(TOPNOTCH)

23

A peptide leukocyte granule constituent which kills microbes by creating holes in their membranes.

Defensins(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.40

24

Predominant form of leukocyte during the first 6 - 24 hours of inflammation.

Neutrophils(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 77

25

Predominant form of leukocyte during 24-48 hrs after the onset of inflammation.

Monocytes(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 77

26

Predominant cellular infiltrate in bacterial infections

Neutrophils(TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 77

27

Predominant cellular infiltrate in viral infections

Lymphocytes (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 77

28

Predominant cellular infiltrate in allergic reactions

Eosinophils (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 77

29

Substances responsible for leukocyte-induced tissue injury

Lysosomal enzymes, reactive oxygen and nitrogen species.(TOPNOTCH)

30

Defective synthesis of CD 18 B-subunit of leukocyte integrins LFA-1 and Mac-1, leading to impaired leukocyte adhesion and migration through endothelium.

Leukocyte adhesion deficiency type 1(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.41

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